Vice President, Nonclinical Drug Safety & Toxicology

Remix Therapeutics•Watertown, MA

About The Position

Remix launched with a vision to transform patients’ lives through modulation of RNA processing. Our breakthrough science enables the identification of small molecules that influence the expression of disease‑driving mRNAs and proteins. We focus on diseases of high unmet medical need and are committed to operating with scientific rigor and urgency. With a proprietary in‑house technology platform, we have rapidly generated multiple discovery programs advancing toward the clinic. Remix Therapeutics was recognized as one of BioSpace’s Best Places to Work in Boston 2025 and is backed by leading life sciences investors. Position Summary: Reporting to the Chief Scientific Officer, the Vice President of Nonclinical Drug Safety and Toxicology is a key position within the R&D leadership team and will lead nonclinical aspects of all the company’s pipeline programs. As the most senior toxicology expert within the organization, the VP will be responsible for providing strategic and operational leadership for the toxicology group across the portfolio of discovery, early development, and late development programs. The Non-Clinical Safety and Toxicology leader will partner cross-functionally across therapeutic areas with colleagues in drug discovery, translational, and clinical development functions, ensuring toxicology and nonclinical safety data is shared and communicated transparently and plays a role in informing strategy at all stages of each program’s development.

Requirements

PhD in toxicology or related discipline with at least 15 years of experience, (an equivalent combination of experience and education may be considered)
Experience in defining and implementing scientifically relevant and compliant nonclinical toxicology strategies and contingency plans addressing both theoretical and identified nonclinical safety issues
Collaborative mindset capable of excelling within multi-discipline discovery and development teams
Proven track record of interfacing with global regulatory authorities, and the design and interpretation of safety studies for regulatory submissions, including INDs and NDAs
Deep knowledge of FDA and EMA requirements and guidance for nonclinical safety submissions
Strong communication (written and oral) and interpersonal skills with an ability to effectively function within a matrixed environment

Nice To Haves

Preferred 10 years of experience managing and developing a drug safety/toxicology team
DABT certification strongly preferred

Responsibilities

Create a long-term global toxicology strategy in alignment with the company’s vision and objectives, including multi-year scientific and operational plans
Lead scientific direction for global regulatory toxicology including safety pharmacology
Lead scientific direction for safety assessments of discovery and early development programs, aligning with program objectives and regulatory strategies
Oversee toxicology findings and provide advice to project teams and senior management on potential impact of results on program goals and probability of success
Collaboratively design and implement external toxicity studies (in vitro and in vivo) required for lead optimization, and development candidate selection
Develop strategy, plan and budget to effectively manage regulatory toxicity studies (in vitro and in vivo) required for IND and NDA submissions, including general toxicity, juvenile toxicity, genotoxicity, safety pharmacology, reproductive and developmental, and carcinogenicity studies
Work with internal R&D leaders and external parties including development partners, consultants, CROs and approved vendors based on a balance of quality, timeliness, and cost
Develop and manage all timelines related to this function
Identify and engage experts in the field of toxicology (e.g., consultants) to interpret study results and make recommendations, as needed
Communicate toxicity study results to discovery program and development teams, and to the company’s executive management and Board of Directors, as needed
Actively participate in regulatory meetings
Other duties as assigned