Vice President, Global Medical Lead - MASH

Madrigal Pharmaceuticals•Waltham, PA

23h

About The Position

Madrigal is a biopharmaceutical company focused on developing therapeutics for metabolic dysfunction-associated steatohepatitis (MASH). Its medication, Rezdiffra (resmetirom), is a once-daily oral, liver-directed THR-β agonist and the first and only medication approved by the FDA and European Commission for MASH with moderate to advanced fibrosis (F2 to F3). A Phase 3 outcomes trial is evaluating Rezdiffra for compensated MASH cirrhosis (F4c). The Global Medical Lead, MASH is accountable for Madrigal’s integrated global medical strategy and plan across the MASH portfolio. Working closely with Medical Affairs leaders and cross-functional stakeholders, the role aligns priorities and investments and coordinates strategy across evidence generation, scientific engagement, diagnostics, lifecycle planning, and external partnerships. The role ensures that medical perspectives are incorporated into enterprise decisions and translated into aligned business and development strategies, while specialist functions lead execution. The position leads and develops a team of Medical Directors supporting MASH, fostering scientific excellence, effective decision-making, and delivery of the integrated strategy to maximize patient impact and portfolio value. It also serves as a senior medical representative and ambassador for the MASH portfolio, integrating internal and external perspectives into portfolio and lifecycle decisions while maintaining independent medical judgment.

Requirements

MD required.
At least 15 years of progressive experience in the pharmaceutical or biotechnology industry.
Substantial Medical Affairs leadership experience at a global or senior regional level.
Robust US launch experience required.
Demonstrated success leading Medical Affairs strategy for a major asset or disease area across product lifecycle stages, including launch and post-launch optimization, with accountability for strategy and execution.
Experience representing Medical Affairs on senior cross-functional asset, brand, development, or lifecycle teams and influencing enterprise decisions across R&D, Commercial, Market Access, and other functions while maintaining independent medical judgment.
Strong experience developing integrated medical and evidence strategies, including prioritizing scientific questions, evidence needs, stakeholder priorities, and investment decisions across the product lifecycle.
Deep scientific and clinical understanding of MASH, hepatology, metabolic disease, or a closely related therapeutic area.
Track record of building, leading, and inspiring large, geographically dispersed, complex global cross-functional teams of scientific and medical professionals.

Nice To Haves

Advanced clinical training in hepatology, gastroenterology, endocrinology, internal medicine, metabolic disease, or a related field.
PhD, MBA, or advanced training in clinical research, outcomes research, health policy, health economics, or business.
Direct experience in MASH, NAFLD/NASH, or liver fibrosis.

Responsibilities

Own the integrated global MASH medical strategy and plan across resmetirom and future MASH assets, ensuring scientific rigor, strategic alignment, and operational deliverability across markets, functions, and product lifecycle stages.
Partner with Medical Affairs leaders to align priorities across evidence, stakeholder engagement, lifecycle planning, and intended outcomes, and coordinate a corporate asset plan across Medical functions.
Translate the MASH medical strategy into actionable objectives, priorities, and measurable outcomes that guide functional strategies and execution.
Incorporate differences among markets, healthcare systems, patient populations, clinical practices, access environments, and treatment pathways; adjust priorities and investments as evidence, stakeholder needs, market dynamics, and portfolio opportunities change.
Make medical prioritization and tradeoff decisions across the MASH portfolio, balancing investments, resources, and organizational focus to maximize impact.
Champion AI-enabled and innovative approaches to improve strategic planning and execution across the MASH portfolio.
Own the integrated MASH evidence strategy, including development and prioritization of asset-level evidence priorities and areas of interest, aligning scientific questions, unmet needs, evidence gaps, and stakeholder needs.
Partner with evidence-generation and other Medical Affairs leaders to translate evidence priorities into appropriate evidence approaches and coordinated functional plans.
Set portfolio priorities for evidence, scientific communication, congresses, and engagement, and translate them into publication, dissemination, advisory board, educational, and stakeholder engagement plans.
Integrate insights from Medical Affairs, R&D, Commercial, Market Access, Diagnostics, International teams, real-world practice, and external experts to refine evidence, communication, and engagement priorities.
Define stakeholder-specific engagement and communication priorities for patients, caregivers, healthcare providers, payers, health systems, advocacy organizations, and policymakers.
Apply AI, advanced analytics, and emerging technologies to improve evidence-gap identification, stakeholder insight generation, prioritization, and impact measurement.
Represent Medical Affairs on the Global Brand Team and in program teams, Medical Leadership team, and lifecycle planning forums, providing the medical perspective and supporting alignment from the outset.
Lead the end-to-end medical strategy and cross-functional Medical Team for resmetirom, integrating Medical Affairs, Commercial, R&D, Market Access, Diagnostics, International Medical Affairs, and other functions.
Serve as the final escalation point and senior medical authority for complex scientific and medical issues requiring risk assessment, cross-functional resolution, or enterprise-level direction.
Synthesize portfolio progress, risks, opportunities, and tradeoffs for senior leadership to support timely decisions and maintain accountability for agreed decisions.
Serve as a senior external medical ambassador for MASH with healthcare experts, scientific leaders, academic institutions, medical societies, HTA bodies, payers, regulatory agencies, and patient advocacy organizations worldwide.
Bring scientific evidence, medical insights, and internal and external stakeholder perspectives into portfolio and lifecycle decisions while maintaining independent medical judgment.
Lead or represent Madrigal at major scientific congresses, policy forums, and clinical forums, bringing external and regional insights into medical strategy and enterprise decision-making.
Champion patient perspectives in scientific strategy, working with medical societies and patient advocacy organizations to ensure disease burden and treatment experience inform the program.
Contribute proactively to commercial planning for the MASH portfolio, ensuring medical insights and evidence-generation strategies inform and strengthen commercial execution.
Lead, develop, and retain a diverse, high-caliber team of Medical Directors supporting the MASH portfolio.
Set objectives, decision rights, performance expectations, and accountabilities across the Medical Director team, including ownership of assigned scope-level medical plans and scientific leadership of selected Medical-sponsored interventional studies.
Foster team members’ ability to challenge perspectives, navigate tradeoffs, collaborate across the organization, and remain accountable for portfolio success measures.
Build a culture of scientific excellence, enterprise thinking, continuous improvement, and responsible AI-enabled work across Medical Affairs, Commercial, and R&D.
Provide mentorship, coaching, career development support, and performance oversight to Medical Directors.
Model Madrigal’s values and culture, championing inclusion, psychological safety, and collaboration.

Benefits

Equity for all employees.
Flexible paid time off.
Medical insurance.
Dental insurance.
Vision insurance.
Life and disability insurance.
401(k) offerings, including traditional and Roth options and employer match.
Voluntary supplemental life insurance.
Legal services.
Mental health benefits through the Employee Assistance Program for employees and their family.
Other benefits in accordance with applicable federal, state, and local laws.