Translational IHC (Consultant)

Legend Biotech US

1d•Remote

About The Position

Legend Biotech is seeking a Translational IHC Consultant as part of the Early Drug Development team based remotely. This role bridges pathology, biomarker and clinical development, ensuring high-quality tissue biomarker data generation to inform baseline, compound MoA, target engagement and safety.

Requirements

Ph.D in Pathology, Immunology, Oncology or related field.
5+ years of experience in Translational biomarker development; IHC/mIF assay development in oncology and immunology.
Deep understanding of TME, Immune cell phenotyping.
Deep understanding of image analysis method such as segmentation, detection and classification, etc.
Experience supporting clinical trials.
Proficiency in image analysis platforms such as HALO, VisioPharm, QuPath, etc.

Nice To Haves

Former biopharma TR/pathology lead preferred

Responsibilities

Collaborate with selected CRO to develop, optimize and validate chromogenic IHC, mIF and spatial Omics as well as ensure assays are phase-appropriate and fit-for-purpose (exploratory to clinical and potential CDx pathway).
Define technical requirement and quality criteria such as antibody selection and qualification, benchmark and scoring algorithms and support GCP-aligned assay validation whenever applicable.
Review study design, validation and analysis reports.
Partner with TR scientists, clinical development and pathologists to translate biological questions and clinical challenges into quantitative image-based endpoints and computational workflows.
Interpret data in collaboration with Translational scientists and pathologists.
Correlate findings with clinical endpoints and peripheral biomarkers from Flow cytometry, cytokine and Omics data.
Provide mechanistic insights in CAR-T infiltration, immune activation and exhaustion and on- and off-target signals.
Documents image processing workflows in compliance with internal SOPs and collaborate with global teams for training and deliverables.
Contribute clinical protocols and regulatory submissions and briefing documents.
Candidate has the authority to make decisions related to methodologies and approaches development processes.
He/she can make decisions related to project execution, including timelines and milestones.
Higher-level approvals are required for those related to significant technical selection, strategic shifts, or major collaborations that have substantial scientific and long-term implications.