Translational Biology Lead, Global Translational Medicine, Oncology Therapy Area, R&D, Orion Corporation
About The Position
We are seeking a scientifically and technically rigorous Translational Biology Lead to advance programs and drive innovation in our oncology pipeline. This role spans both biomarker discovery and assay development, as well as translational research with fit-for-purpose preclinical models to inform data-driven decisions in clinical development. The successful candidate is expected to bring deep expertise in at least one of these domains, with a strong foundation and demonstrated interest in the other. The position is designed to enable cross-functional growth, providing opportunities to expand capabilities across both areas while driving integrated, end-to-end translational strategies.
Requirements
- PhD in Cancer Biology, Biomedical Sciences, or related field and ≥4 years experience in oncology biomarkers assay development and / or preclinical research within biotech/pharma or academic
- MS in Biology, Pharmacology, or related field and ≥8 years experience in oncology biomarkers assay development and / or preclinical research within biotech/pharma or academic
- Broad subject matter expertise in key technical aspects of various biomarker assays (e.g. Flow cytometry, IHC.)
- Strong expertise in diverse pre-clinical models (in vitro, ex vivo, in vivo) related to oncology and immune-oncology
- Demonstrated experience in the appropriate application of various scientific technologies into translational insights
Nice To Haves
- Strong oncology drug development experience
- Familiarity with technical and regulatory considerations of clinical biomarker and CDx development
- Excellent communication and presentation skills, including the ability to interact with senior leaders and external partners
- Strong external collaboration network (academia, CROs, biobanks)
Responsibilities
- Discover biomarkers for patient selection, target engagement, and pharmacodynamic (PD) effects
- Drive design, development, validation, verification and implementation of translational and clinical-grade biomarker assays to inform essential clinical research questions
- Ensure biomarker studies comply with GXP and other relevant regulatory standards. Partner with internal collaborators to identify and qualify CROs and other vendors appropriately.
- Explore and apply innovative technologies (e.g., spatial omics, digital pathology) to advance biomarker development
- Characterize targets (expression, stability, heterogeneity) to inform indication and patient selection strategies
- Partnering with internal and external collaborators to develop and apply state-of-the-art in vitro, in vivo and ex-vivo models of oncology and Immuno-oncology to inform indication selection, patient selection, Mechanism of action, Mechanism of resistance and combination strategy
- Lead study design, execution oversight, and rigorous analysis/interpretation of preclinical models to generate insights to support clinical development plan
- Evaluate and implement innovative technologies and platforms that increase rigor, throughput, translational relevance, and decision quality from pre-clinical models
Benefits
- Continuous learning
- Competitive salary
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
