Technical Development Principal Scientist, Mass Spectrometry Characterization Lead

Genentech • Daly City, CA

6d • $120,800 - $224,300

About The Position

Join Genentech’s global Analytical Development and Quality Control team to lead analytical strategies for biologic therapeutics from early development through commercialization. The role combines strategic leadership and hands-on laboratory expertise in a collaborative, multidisciplinary environment.

The position leads mass spectrometry characterization strategy and execution, designs and interprets complex LC-MS analyses, develops phase-appropriate methods and multi-attribute method strategies, and identifies and monitors critical quality attributes and post-translational modifications. It supports process development milestones, authors filing-ready MS characterization sections for global regulatory submissions, represents technical packages in regulatory interactions, collaborates with internal and external teams, and mentors scientific team members.

Relocation benefits are available. The expected salary range for the primary location of South San Francisco, California, is $120,800–$224,300. Actual pay depends on experience, qualifications, geographic location, and other permitted job-related factors. A discretionary annual bonus may be available based on individual and company performance. The position qualifies for the company’s benefits, which are detailed at a linked page not included in the posting.

Requirements

• Ph.D. with 4–6+ years of relevant experience, or M.S./B.S. with 6–10+ years of relevant experience.
• Degree in Analytical Chemistry, Biochemistry, Chemical Engineering, or a related field.
• Deep expertise in LC-MS applied to characterization of proteins or related therapeutic modalities.
• Strong working knowledge of CMC drug development and regulatory filing processes, including IND and BLA.
• Excellent collaboration, organizational, and communication skills.
• Ability to work independently as a lead and as part of a multidisciplinary team.
• Agile problem-solving, scientific curiosity, commitment to technical quality, and ability to deliver results in a fast-paced environment.

Responsibilities

• Lead mass spectrometry characterization strategy and execution across biologic therapeutic development, from early development through commercial launch.
• Design, execute, and interpret complex LC-MS analyses to establish structural understanding of protein modalities and resolve technical root causes.
• Develop and implement phase-appropriate MS methods and advanced multi-attribute method strategies where standard analytical assays are insufficient.
• Identify, monitor, and quantify critical quality attributes and post-translational modifications.
• Support process development milestones, including cell line selection, purification, formulation, stability, minor variant characterization, and structure-function elucidation.
• Author filing-ready MS characterization sections for global IND, BLA, and MAA submissions and represent technical packages in regulatory interactions.
• Collaborate with multidisciplinary teams, analytical leads, and external research and manufacturing partners to achieve project milestones.
• Mentor scientific team members in MS data interpretation and champion modern analytical capabilities and best practices.

Benefits

• Relocation benefits are available.
• A discretionary annual bonus may be available based on individual and company performance.
• The position qualifies for company benefits; specific benefits are not detailed in the posting.

What This Job Offers

• Job Type: Full-time
• Career Level: Principal