Synthetic DNA Process Development Scientist
About The Position
Eurofins USA Genomic Services is seeking an Organic Chemist with expertise in oligonucleotide synthesis and purification to support process development and manufacturing. The role focuses on developing, optimizing, and scaling chemical processes for high-throughput, high-quality oligonucleotide production. The scientist will work with manufacturing, quality control, and engineering teams to transfer processes and improve production methods, and will mentor laboratory technicians. The position is full-time, Monday through Friday from 8:00 a.m. to 5:00 p.m., with overtime and weekend work as needed. Candidates within commuting distance of Louisville, Kentucky, are encouraged to apply.
Requirements
- Ph.D. or Master’s degree in Organic Chemistry or a related field.
- At least 5 years of industrial experience in chemical synthesis.
- Hands-on experience with solid-phase oligonucleotide synthesis.
- Hands-on experience in oligonucleotide purification process development.
- Strong analytical skills, including HPLC and LC-MS.
- Experience scaling processes to manufacturing.
- Authorization to work indefinitely in the United States without restriction or sponsorship.
- Ability to manage multiple priorities.
Nice To Haves
- Experience in GMP or regulated environments.
- Familiarity with automated DNA/RNA synthesizers.
- Knowledge of modified nucleotides.
- Experience in high-throughput oligonucleotide production.
- Ability to provide occasional off-hours support as needed.
Responsibilities
- Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides.
- Develop and scale processes from research and development to manufacturing.
- Develop and improve oligonucleotide purification processes, including HPLC, ion-exchange, and desalting.
- Troubleshoot synthesis and purification challenges to improve yield and purity.
- Collaborate with manufacturing, quality control, and engineering teams on process transfer.
- Evaluate new chemistries and technologies.
- Author standard operating procedures, batch records, and technical reports.
- Ensure compliance with quality systems.
- Mentor laboratory technicians.
Benefits
- Comprehensive medical coverage
- Dental insurance
- Vision options
- Life insurance
- Disability insurance
- 401(k) with company match
- Paid vacation
- Paid holidays
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What This Job Offers
Job Type
Full-time
Career Level
Senior
