Synthetic DNA Process Development Scientist

Eurofins USA Genomic Services • Louisville, KY

1d

About The Position

Eurofins USA Genomic Services is seeking an Organic Chemist with expertise in oligonucleotide synthesis and purification to support process development and manufacturing. The role focuses on developing, optimizing, and scaling chemical processes for high-throughput, high-quality oligonucleotide production, including transferring processes from research and development to manufacturing. The position is full-time, Monday through Friday, 8:00 a.m. to 5:00 p.m., with overtime and weekend work as needed. Candidates within commuting distance of Louisville, Kentucky, are encouraged to apply.

Requirements

• Ph.D. or master’s degree in Organic Chemistry or a related field.
• At least 5 years of industrial experience in chemical synthesis.
• Hands-on experience with solid-phase oligonucleotide synthesis.
• Hands-on experience in oligonucleotide purification process development.
• Strong analytical skills, including HPLC and LC-MS.
• Experience scaling processes to manufacturing.
• Authorization to work in the United States indefinitely without restriction or sponsorship.
• Ability to manage multiple priorities.
• Availability to provide occasional off-hours support as needed.

Nice To Haves

• Experience in GMP or regulated environments.
• Familiarity with automated DNA/RNA synthesizers.
• Knowledge of modified nucleotides.
• Experience in high-throughput oligonucleotide production.

Responsibilities

• Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides.
• Develop and scale processes from research and development to manufacturing.
• Develop and improve oligonucleotide purification processes, including HPLC, ion-exchange, and desalting.
• Troubleshoot synthesis and purification challenges to improve yield and purity.
• Collaborate with manufacturing, quality control, and engineering teams on process transfer.
• Evaluate new chemistries and technologies.
• Author standard operating procedures, batch records, and technical reports.
• Ensure compliance with quality systems.
• Mentor laboratory technicians.

Benefits

• Comprehensive medical coverage
• Dental coverage options
• Vision coverage options
• Life insurance
• Disability insurance
• 401(k) with company match
• Paid vacation
• Paid holidays

What This Job Offers

• Job Type: Full-time
• Career Level: Senior