Summer Intern/DMPK PBPK Modeling
About The Position
This position offers a unique opportunity to develop advanced ADC PBPK modeling skills within the DMPK Modeling group. The PBPK science Co-op will contribute to establishing a generic, reusable payload PBPK framework in Simcyp, applicable across diverse ADC modalities. This work will encompass: Comprehensive characterization of ADC payload ADME using both internal and published data. Independent development and validation of PBPK model for ADC payloads in Simcyp, often utilizing Trastuzumab-based ADCs as an exemplar system to explore mAb PK, linker stability, and payload exposure. Integration of mechanistic data or QSAR-predicted parameters to ensure broad applicability of models, identifying key data gaps and informing future ADC design strategies. Collaboration across various cross-functional teams (toxicology, biology, chemistry, clinical pharmacology, formulations) to apply model-informed drug development strategies for ADCs. Work towards building a template PBPK model in Simcyp for multiple ADC payload chemotypes, integrating mechanistic sub-models or QSAR-based predictions. Present modeling outputs in internal team and department meetings. The goal is to be able to generate a high-impact publication detailing the generic ADC payload PBPK model and its applications.
Requirements
- Pursuing a Master's or PhD in a relevant scientific discipline (Pharmacokinetics, Pharmacology, Biochemistry or other DMPK related sciences).
- Must be able to work full-time (35-40 hours/week) throughout the duration of the 3 to 6-month internship (May/June ~ August to December 2026).
- Must have an active student status and/or within 12 months post-graduation from a BS or MS degree program.
- Post-doctoral candidates are not eligible.
- Must successfully pass a drug screen and background check prior to assignment target start date.
- A passing score is required on the GSK Digital Assessment.
Nice To Haves
- Experience with application of PBPK software SimCYP.
- Basic knowledge of DMPK processes in drug discovery and development.
- Basic understanding of the in vitro/in vivo experiments used to describe general ADME principles especially drug absorption and drug distribution.
- Scientific writing and presentation ability with excellent verbal communication skills.
Responsibilities
- Contribute to establishing a generic, reusable payload PBPK framework in Simcyp, applicable across diverse ADC modalities.
- Characterize ADC payload ADME using both internal and published data.
- Develop and validate PBPK models for ADC payloads in Simcyp, often utilizing Trastuzumab-based ADCs as an exemplar system to explore mAb PK, linker stability, and payload exposure.
- Integrate mechanistic data or QSAR-predicted parameters to ensure broad applicability of models, identify key data gaps, and inform future ADC design strategies.
- Collaborate across various cross-functional teams (toxicology, biology, chemistry, clinical pharmacology, formulations) to apply model-informed drug development strategies for ADCs.
- Build a template PBPK model in Simcyp for multiple ADC payload chemotypes, integrating mechanistic sub-models or QSAR-based predictions.
- Present modeling outputs in internal team and department meetings.
- Generate a high-impact publication detailing the generic ADC payload PBPK model and its applications.
Benefits
- Relocation stipend for candidates hired for an on-site or hybrid role who reside outside of 50-miles from their assigned work location.
- Competitive hourly pay rate.
- Medical benefits (provided by Atrium).
- Fringe benefits (provided by Atrium).
- Overtime pay, in accordance with federal and state requirement.
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What This Job Offers
Job Type
Full-time
Career Level
Intern
