Summer Intern/DMPK PBPK Modeling

GSK Internships & Co-ops powered by Atrium • Upper Providence, PA

17h • Onsite

About The Position

This position offers a unique opportunity to develop advanced ADC PBPK modeling skills within the DMPK Modeling group. The PBPK science Co-op will contribute to establishing a generic, reusable payload PBPK framework in Simcyp, applicable across diverse ADC modalities. This work will encompass:

Comprehensive characterization of ADC payload ADME using both internal and published data.
Independent development and validation of PBPK model for ADC payloads in Simcyp, often utilizing Trastuzumab-based ADCs as an exemplar system to explore mAb PK, linker stability, and payload exposure.
Integration of mechanistic data or QSAR-predicted parameters to ensure broad applicability of models, identifying key data gaps and informing future ADC design strategies.
Collaboration across various cross-functional teams (toxicology, biology, chemistry, clinical pharmacology, formulations) to apply model-informed drug development strategies for ADCs.
Work towards building a template PBPK model in Simcyp for multiple ADC payload chemotypes, integrating mechanistic sub-models or QSAR-based predictions.
Present modeling outputs in internal team and department meetings.
The goal is to be able to generate a high-impact publication detailing the generic ADC payload PBPK model and its applications.

Requirements

• Pursuing a Master's or PhD in a relevant scientific discipline (Math, Pharmacology, Biochemistry or other DMPK related sciences).
• Must be able to work full-time (35-40 hours/week) throughout the duration of the 3 to 6-month internsip (May/June ~ August to December 2026).
• Must have an active student status and/or within 12 months post-graduation from a BS or MS degree program.
• Post-doctoral candidates are not eligible.
• Must successfully pass a drug screen and background check prior to assignment target start date.
• A passing score is required to proceed in the application process after completing the immersive GSK Digital Assessment.

Nice To Haves

• Experience with application of PBPK software SimCYP.
• Basic knowledge of DMPK processes in drug discovery and development.
• Basic understanding of the in vitro/in vivo experiments used to describe general ADME principles especially drug absorption and drug distribution.
• Scientific writing and presentation ability with excellent verbal communication skills.

Responsibilities

• Comprehensive characterization of ADC payload ADME using both internal and published data.
• Independent development and validation of PBPK model for ADC payloads in Simcyp, often utilizing Trastuzumab-based ADCs as an exemplar system to explore mAb PK, linker stability, and payload exposure.
• Integration of mechanistic data or QSAR-predicted parameters to ensure broad applicability of models, identifying key data gaps and informing future ADC design strategies.
• Collaboration across various cross-functional teams (toxicology, biology, chemistry, clinical pharmacology, formulations) to apply model-informed drug development strategies for ADCs.
• Work towards building a template PBPK model in Simcyp for multiple ADC payload chemotypes, integrating mechanistic sub-models or QSAR-based predictions.
• Present modeling outputs in internal team and department meetings.

Benefits

• Relocation stipend for candidates hired for an on-site or hybrid role who reside outside of 50-miles from their assigned work location.
• Competitive hourly pay rate
• Medical benefits
• Fringe benefits
• Overtime pay, in accordance with federal and state requirement.

What This Job Offers

• Job Type: Full-time
• Career Level: Intern
• Number of Employees: 5,001-10,000 employees