Staff Scientist, Research (Oncology Diagnostics)

Natera•San Carlos, CA

30d•$157,300 - $196,600•Onsite

About The Position

Natera is seeking a Staff Scientist to join our Early Research Team. The primary focus of this role is to independently lead the research and development of novel next-generation sequencing (NGS) technologies. In this role, you will lead projects from ideation to prototype, specifically designing and optimizing high-complexity NGS methods to advance our oncology diagnostic portfolio. Success in this role requires a deep technical foundation in molecular biology and NGS plus a proven track record of industrial R&D leadership.

Requirements

Ph.D. in molecular biology, genomics, or a closely related field.
Minimum 8 years of relevant industry experience, or 2+ years postdoctoral research with 6+ years in industry.
Proven experience in designing and advancing NGS-based diagnostics, preferably in the field of oncology.
A strong technical foundation in molecular biology or chemistry.
Deep mechanistic knowledge of NGS library preparation chemistry.
Demonstrated ability to independently design and execute complex experiments (solid DOE skills).
Creativity and ingenuity in solving high-ambiguity technical challenges.
Experience leading research projects in an industrial setting.

Nice To Haves

Experience with cfDNA or liquid biopsy assay development.
Hands-on experience with NGS-based methylation detection and epigenomic workflows.
Familiarity with translating early-stage research assays toward regulated product environments.
Proficiency in statistical analysis tools such as Excel, JMP, R, or Python; familiarity with bioinformatics workflows is a plus.

Responsibilities

Lead and manage the development of innovative NGS-based diagnostic assays from feasibility through optimization.
Define project goals and plans with input from stakeholders and manage multiple project streams in parallel.
Independently design and execute complex laboratory experiments; analyze and interpret results to guide research direction.
Coordinate cross-functional efforts to meet milestones and collaborate closely with bioinformatics, statistics, and data science teams to ensure robust experimental design and data analysis.
Mentor and guide junior scientists while promoting scientific rigor and best practices.
Author high-quality protocols, technical reports, and study documentation.
Communicate progress regularly to stakeholders, including departmental meetings and senior leadership.
Contribute to risk management, strategy development, and continuous improvement of scientific workflows.