Staff Scientist, R&D

Natera•Austin, TX

1d•Onsite

About The Position

We are looking for a highly motivated Staff Scientist within the Molecular Biology product development team to join a cross-functional team of scientists who are tasked with developing and advancing Natera’s oncology product portfolio. The Staff Scientist will be working with internal cross functional teams and investigating the feasibility of applying a variety of scientific principles and concepts to oncology diagnostics and monitoring space. The ideal candidate is a driven professional who maintains broad knowledge of state-of-the-art principles and theories with an in-depth understanding of applicability to oncology research. We are looking for a meticulous and dedicated scientist with experience in both NGS assay development and high throughput automation that can work effectively in a fast-paced environment to ensure that the highest quality clinical assays are developed and launched for our patients.

Requirements

MS with 10 years or PhD with at least 7+ years of experience in assay development and automation for the life science industry
Demonstrated track record of development and validation of automated protocols for CLIA labs
Experience developing, implementing, optimizing, and troubleshooting high-throughput automated assays utilizing liquid handler robots
Strong understanding of the chemistry underlying nucleic acid extraction, NGS library preparation, and hybrid capture technologies
Strong individual contributor as well as dedicated team player
Experience designing and executing studies including stability, guard banding, reproducibility and repeatability, and validation
Experience working in a regulated laboratory environment under CLIA/CAP, NYSDOH, IVD is a plus
Excellent communication, organizational, record-keeping, planning, attention to detail and time management skills
Ability to collaborate cross-functionally with other groups (CLIA, LIMS, lab operations QA, Automation, Research)

Nice To Haves

Data analysis (JMP) required, coding skills (Python or R), and liquid handler programming experience are a plus

Responsibilities

Lead technical projects and associated timelines and deliverables in NGS-based assays as a subject matter expert.
Represent the biodevelopment group in cross-functional project teams
Design, develop, and validate automated high-throughput NGS assays that will be run in a commercial CLIA laboratory
Mentor junior employees
Design and execute high complexity experiments and perform data analysis (e.g. JMP, Python, R, Excel)
Collaborate with assay development scientists on the specifications of assay, reagent, equipment and quality metrics for existing and future production assays
Work with Clinical Laboratory directors and Quality Assurance to ensure that developed methods meet Natera’s rigorous quality standards
Coordinate with multiple internal groups (automation engineering, laboratory operations, bioinformatics, statistics, project and product management) and serve as point person to ensure the successful identification and timely execution of projects
Write documentation and SOPs, and train lab operations operators on protocols. Oversee validation activities
Participate in post-launch surveillance by troubleshooting production issues, performing root cause analysis on automation, reagent, peripheral equipment and assay failures
Identify areas for continuous improvement and actively contribute to the effort of introducing better practices to improve production workflows and shorten TAT for patient samples