ER dysfunction and protein misfolding disease is an emerging field. The overall goals of our research are to delineate the molecular mechanisms underlying ER stress-mediated kidney diseases, including nephrotic syndrome (NS), Alport syndrome, autosomal dominant tubulointerstitial kidney disease (ADTKD) and other acquired forms of ER disease, to develop ER stress biomarkers in human patients, and to identify ER stress modulators. We are using cutting-edge research approaches, including stably transfected or knock-down cells, molecular and cell biology, biochemistry, inducible transgenic, conditional knock-out and CRISPR generated knock-in mouse models, human iPSCs derived from patients, and state-of-the-art in vitro & in vivo imaging techniques. The PI’s research has been funded by multiple grants from NIH, VA Merit and industry. The lab environment is highly supportive for further scientific training and career development. Designs research protocols. Assists in developing and conducting research projects, including experiment design, data analysis and documentation of experiment results.
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Job Type
Full-time
Career Level
Mid Level