Staff Scientist - Metabolomics

University of Chicago•Chicago, IL

6d•Onsite

About The Position

The Duchossois Family Institute (DFI) studies how the microbiome influences susceptibility to infectious, inflammatory, and autoimmune disease. Using a multi-omic approach and mass spectrometry-based metabolomics, the DFI identified and characterizes gut metabolites to understand microbe-microbe and host-microbe interactions. The team supports the University of Chicago and external researcher through experimental design, custom analyses, and data visualization, while also developing rapid, same-day quantitative assays to help clinicians assess gut microbiome health in clinical settings. The DFI partners with The University of Chicago Advanced Technology (UCAT) Laboratory, a CLIA-licensed, CAP-accredited clinical lab within the Department of Pathology specializing in liquid chromatography-mass spectrometry. Together, they develop, validate, and deliver same-day, mass spectrometry-based diagnostics that translate microbiome science into actionable patient care. The job facilitates and promotes a research project or contributes to the scientific direction of a research resource. Receives a moderate level of guidance and direction. The Staff Scientist - Metabolomics will collaborate with a dynamic team of scientists, clinicians, and industry partners on cutting-edge metabolomics research — designing studies, performing targeted and untargeted LC and GC-MS experiments, elucidating unknown compounds, and contributing to publications. On the clinical side, the Staff Scientist – Metabolomics will develop and validate quantitative same-day assays in a CLIA-licensed, CAP-accredited lab, translating microbiome science into actionable diagnostics for patients enrolled in clinical trials.

Requirements

PhD in related field.
2-5 years of work experience in a related job discipline.

Nice To Haves

Spearheaded mass spectrometry-based metabolic quantitation withing a CLIA/CAP regulated environment, ensuring rigorous compliance with clinical quality standards and method validation requirements.
3+ years of hands-on expertise across the full MS data spectrum – targeted, untargeted, and quantitative workflows – to drive actionable insights and support high-throughput analytical pipelines.
Established track record analyzing microbially derived metabolites across complex biological systems, with focused in gut microbiome metabolomics from both human and murine models.
End-to-end proficiency in GC-MS and LC-MS analytical pipelines across targeted and untargeted metabolomic workflows, from method development and sample preparation through data acquisition, analysis, and reporting; including experience with complex biological matrices and CLIA/CAP-regulated environments.
Proven ability to work effectively across multidisciplinary teams and communicate complex data clearly to diverse scientific and clinical audiences.
Detail-oriented and deadline-driven, with rigorous record-keeping practices and the ability to manage multiple priorities simultaneously without sacrificing quality.

Responsibilities

Collaborate with internal teams, academic/industry partners, and UChicago clinical staff on study design and data interpretation.
Maintain and troubleshoot LC and GC-MS instruments; perform targeted and untargeted metabolomics experiments.
Support structural elucidation of unknown compounds; and contribute to data analysis, visualizations, and manuscripts as needed.
Develop quantitative same-day blood and fecal assays for a CLIA/CAP clinical lab.
Author SOPs covering sample handling, data collection, QC validation, and instrumentation logs; maintain reagents, solvents, calibrators, and QC materials.
Enforce BSL-2 and chemical safety protocols; execute daily (Mon–Fri) sample testing and data reporting for clinical trials; and coordinate sample logistics and results communication with clinical and DFI teams.
Serves as a resource for collecting data and performing analysis.
Contributes to facilitating and promoting a research project by providing scientific or intellectual information.
Reviews laboratory protocols and training on new techniques.
Manage complex data sets for research.
Leads the contributions to scientific writing and publications, including protocols and grants.
Performs other related work as needed.