UNIV - Staff Scientist III - Department of Biochemistry

Medical University of South Carolina•Charleston, SC

4d•Onsite

About The Position

Seeking a highly motivated individual to fill a Senior Staff Scientist position in a cancer research laboratory in the Department of Biochemistry and Molecular Biology at the Medical University of South Carolina. Current work in the laboratory is centered on lipid metabolism in relation to hypoxia and drug resistance in prostate cancer. This is a non-tenure track position, with renewal dependent on continued availability of extramural funding. Salary range is commensurate with experience.

Requirements

Ph.D. with considerable experience in molecular biology, biochemistry, and cell biology.
Experience in utilizing in vivo models of prostate cancer and surgical techniques.
Strong track record in publishing high impact research.
History of training and oversight of graduate students, postdoctoral fellows, and other research staff.
Eligible for employment in the U.S.
Ability to perform job functions in an upright position (Continuous).
Ability to perform job functions in a seated position (Continuous).
Ability to perform job functions while walking/mobile (Frequent).
Ability to work indoors (Continuous).
Ability to work in all cold temperature extremes, i.e. spot coolers (Frequent).
Ability to bend at the waist (Frequent).
Ability to twist at the waist (Frequent).
Ability to perform 'pinching' operations (Continuous).
Ability to fully use both hands/arms (Continuous).
Ability to perform repetitive motions with hands/wrists/elbows and shoulders (Continuous).
Ability to fully use both legs (Continuous).
Ability to reach in all directions (Continuous).
Possess good finger dexterity (Continuous).
Ability to maintain tactile sensory functions (Continuous).
Ability to maintain good olfactory sensory function (Continuous).
Ability to lift and carry 30 lbs., unassisted (Frequent).
Ability to lift objects, up to 30 lbs., from floor level to height of 72 inches, unassisted (Frequent).
Ability to lower objects, up to 30 lbs., from height of 72 inches to floor level, unassisted (Frequent).
Ability to maintain 20/40 vision, corrected (Continuous).
Ability to see and recognize objects close at hand (Continuous).
Ability to see and recognize objects at a distance (Continuous).
Ability to match or discriminate between colors (Continuous).
Ability to determine distance/relationship between objects; depth perception (Continuous).
Good peripheral vision capabilities (Continuous).
Ability to maintain hearing acuity, with correction (Continuous).
Ability to perform gross motor functions with frequent fine motor movements (Continuous).
Ability to be qualified physically (by medical personnel) for respirator use, initially and annually.
Ability to work alone in isolated areas, such as darkrooms (Frequent).
Ability to obtain and maintain a valid driver's license.
Computer literacy.
Ability to learn and use new processes, tools and equipment as required.

Nice To Haves

Ability to climb stairs (Infrequent).
Ability to push/pull objects, up to 50 lbs., unassisted (Infrequent).
Ability to lift and carry objects up to 30 lbs. a distance of five (5) floors and to outlying buildings (Frequent).

Responsibilities

Develop an independent research project in consultation with the PI, including design and implementation of in vitro experiments to assess lipid alterations that impact drug sensitivity.
Review current scientific literature, maintain meticulous laboratory records, and present results to PI in individual and group meetings.
Draft and publish results in leading scientific journals and work closely with PI to develop research grant proposals.
Perform in vivo experiments to assess drug efficacy and differential biology in prostate cancer, including orthotopic models of prostate cancer and bone orthotopic models of metastasis.
Lead in vitro and in vivo testing of novel inhibitors identified and developed by the lab and its collaborators.
Perform pK studies, urological surgeries in mice and all modalities of drug delivery, including intraperitoneal, oral gavage, retro-orbital, and tail vein injections, among others, as well as necropsy and tissue collection from primary and distant organs.
Train and supervise technical staff, graduate students, and other laboratory personnel, including mentoring students.
Oversee equipment, develop written protocols of experimental techniques, and advise and assist junior members of the laboratory on experimental approaches.
Manage daily lab needs, activity, and budgeting.
Maintain databases of laboratory reagents, cell lines, and order supplies.