UNIV - Staff Scientist I - Department of Biochemistry

Medical University of South Carolina•Charleston, SC

10d•Onsite

About The Position

A Staff Scientist is needed to conduct and coordinate translational cancer research focused on understanding molecular mechanisms of tumor progression and therapeutic response, as well as identifying novel therapeutic strategies for solid tumors. The successful candidate will join a collaborative research group integrating molecular and cellular biology, cancer pharmacology, tumor immunology, and preclinical models to investigate cancer vulnerabilities and advance new therapeutic approaches.

Requirements

A PhD, MD, or equivalent doctoral degree in cancer biology, molecular biology, biochemistry, pharmacology, or related biomedical discipline with a minimum of two years of postdoctoral experience is desired.

Nice To Haves

Experience in cancer biology, molecular and cellular biology, and/or cancer pharmacology is desired.
Mammalian cell culture
Molecular biology
Protein biochemistry
Cell death and stress-response pathways
Flow cytometry
Microscopy
Drug-response assays
Genetic manipulation of cancer and normal cells
Preclinical tumor models
Bioinformatics, genomic or transcriptomic data analysis, quantitative analysis, or other computational approaches is a plus.
Experience studying gastrointestinal cancers (including pancreatic, colorectal, liver cancer) and other solid tumors is also desirable.
Ability to obtain and maintain a valid drivers license.
Computer literacy.
Ability to learn and use new processes, tools and equipment as required.

Responsibilities

Conduct basic and translational studies investigating molecular mechanisms that regulate cancer cell survival, therapeutic response and resistance, and tumor progression.
Design and perform experiments, analyze and interpret data, contribute to the development of new experimental approaches, and work closely with the Principal Investigator and collaborators on manuscripts, presentations, and research grant proposals.
Assist with training and supervision of undergraduate and graduate students, postdoctoral fellows, research staff, and visiting scholars.
Design, coordinate, and perform studies examining molecular mechanisms of cancer progression, therapeutic response, and resistance.
Conduct drug-response and combination studies and evaluate candidate therapeutic targets using established cancer models.
Maintain and experimentally manipulate human and murine normal and cancer cell lines, along with other relevant cancer models.
Perform genetic and pharmacologic perturbation studies as needed.
Perform molecular biology, cell biology, and biochemical techniques, including Western blotting, quantitative PCR, RNA and protein isolation, immunostaining, microscopy, and related assays.
Perform flow cytometry, cell proliferation and viability assays, cell death assays, cytokine or immune-related assays, and other functional studies relevant to cancer biology and therapeutic response.
Analyze experimental and high-dimensional datasets using appropriate statistical and quantitative approaches and integrate results across experimental platforms.
Work closely with the Principal Investigator and collaborators to prepare manuscripts, presentations, and research grant proposals and contribute to the development of new research directions.
Assist with training and supervision of students, postdoctoral fellows, research staff, and visiting scholars.
Maintain accurate laboratory records and ensure compliance with institutional biosafety requirements; organize and maintain research equipment as needed.