Staff Scientist I, Data Science
About The Position
The Lieber Institute for Brain Development (LIBD) is an independent medical research institute focused on understanding how genes and the environment shape brain development and contribute to developmental brain disorders. Located in Baltimore, Maryland, LIBD conducts multidisciplinary research aimed at identifying new treatments and prevention strategies. The Staff Scientist will work in the Neural Plasticity division on computational biology and bioinformatics research into the molecular organization, development, and function of brain circuits involved in psychiatric disorders. The team combines molecular profiling of postmortem human brain tissue with experimental mouse studies and human induced pluripotent stem cell (iPSC) and organoid models. The successful candidate will lead analyses of single-nucleus RNA sequencing, spatial transcriptomics, and other multiomic datasets generated by the team and its collaborators. The role also offers opportunities to develop computational approaches, shape research questions, and collaborate with experimental scientists to connect molecular findings with cellular organization, circuit function, and behavior.
Requirements
- Master’s degree or higher in Computational Biology, Bioinformatics, Biostatistics, Genetics, Neuroscience, or a related field; a PhD is preferred.
- At least 2 years of related experience.
- Proficiency in Linux and programming with R or Python.
- Demonstrated experience analyzing large-scale transcriptomic or other genomic datasets, particularly single-nucleus and spatial transcriptomics data.
- Strong understanding of statistical analysis, including experimental design, regression or mixed-effects models, multiple testing, and sources of technical and biological variation.
- Familiarity with high-performance computing, version control, and reproducible analysis practices.
- Ability to independently develop analytical strategies, troubleshoot computational problems, and critically evaluate results.
Nice To Haves
- Expertise in asking and interpreting biological questions underlying the data and communicating findings clearly to colleagues with varied computational and experimental backgrounds is highly desired.
- Previous experience working on genomics datasets related to neuroscience or psychiatry is preferred but not required.
- PhD.
Responsibilities
- Analyze and interpret large-scale genomic and multiomic datasets from human brain tissue, mouse and organoid models, and public resources.
- Develop and apply computational and statistical approaches to research questions in neuroscience and psychiatric disorders.
- Develop and maintain reproducible analysis workflows, including responsibility for data quality, documentation, and organization.
- Prepare scientific figures, write and revise manuscripts, and contribute to grant applications with research teams.
- Present research findings at team meetings and scientific conferences.
- Perform other duties as assigned.
Benefits
- Competitive, comprehensive benefits package; details are available on the employer’s benefits webpage.
- Opportunities for employee growth over time.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
