Staff Research Associate

UCSF•San Francisco, CA

9d•Onsite

About The Position

The UCSF Hair Analytical Laboratory (HAL) analyzes antiretroviral, anti-tuberculosis (anti-TB), antibiotic, and controlled substance concentrations in hair (but may include other biological specimens such as urine, dried blood spot (DBS), plasma, serum, whole blood, nail, saliva, etc.) in the context of HIV and TB prevention and treatment studies using assays that are developed and validated according to the Federal Food and Drug Administration’s (FDA’s) guidelines for bioanalytical methods and the National Institute of Health’s (NIH’s) Division of AIDS’ (DAIDS) Clinical Pharmacology Quality Assurance Program (CPQA). This position is responsible for overseeing and maintaining high-quality regulatory functions in the laboratory. This HAL Staff Research Associate I position will assist senior analysts in determining drug concentrations in samples utilizing validated high-performance liquid chromatographic (HPLC)-tandem mass spectrometric (LC-MS/MS) bioanalytical methods.

Requirements

Utilizing high-performance liquid chromatography (HPLC)-tandem mass spectrometry (LC/MS/MS) analytical methods
Laboratory data management system (LDMS)
Operating and calibrating analytical instruments
Using and calibrating micropipettes
Thorough documentation in lab books, log books, and paperwork
Validation of LC/MS/MS methods
Federal Food and Drug Administration’s (FDA’s) Good Laboratory Practice (GLP)
National Institute of Health’s (NIH’s) Division of AIDS’ (DAIDS) Clinical Pharmacology Quality Assurance (CPQA) regulatory guidelines
Validated high-performance liquid chromatographic (HPLC)-tandem mass spectrometric (LC-MS/MS) bioanalytical methods

Responsibilities

Quantitate drug concentrations for anti-human immunodeficiency virus (HIV) and anti-tuberculosis (TB) medications, antibiotics, and controlled substances primarily in human hair, dried blood spot (DBS), and urine samples (but may include other biological specimens, such as whole blood, plasma, serum, nail, saliva, etc.), utilizing high-performance liquid chromatography (HPLC)-tandem mass spectrometry (LC/MS/MS) analytical methods for pharmacokinetic, compliance, and efficacy studies.
Log in samples via a laboratory data management system (LDMS).
Sample preparation.
Operate and calibrate analytical instruments.
Use and calibrate micropipettes.
Thorough documentation in lab books, log books, and paperwork.
Perform analysis (and subsequent interpretation) of data.
Assist in the validation of LC/MS/MS methods for antiretroviral and anti-TB drug analysis in hair, but may also include other biological specimens, in compliance with the Food and Drug Administration’s (FDA’s) Good Laboratory Practice (GLP) and National Institute of Health’s (NIH’s) Division of AIDS’ (DAIDS) Clinical Pharmacology Quality Assurance (CPQA) regulatory guidelines.
Oversee and maintain high-quality regulatory functions in the laboratory.
Assist senior analysts in determining drug concentrations in samples utilizing validated high-performance liquid chromatographic (HPLC)-tandem mass spectrometric (LC-MS/MS) bioanalytical methods.