Sr./Staff Scientist – Surface Chemistry

Sarmal Inc•San Diego, CA

8d•$125,000 - $162,000•Onsite

About The Position

We are seeking a Senior Scientist to Staff Scientist Surface Chemist to drive the design, development, and optimization of functionalized surfaces for next-generation sequencing (NGS), and molecular diagnostic (IVD) platforms. This role sits at the interface of chemistry, materials science, and device engineering, and is responsible for developing robust, manufacturable surface chemistries (including hydrogel, silane, self-assembled monolayers, brush polymer surfaces) for ultra-low fouling, oligonucleotide/probe immobilization, hybridization and various molecular processes. The ideal candidate brings deep hands-on expertise in various surface chemistry methods, thin-film deposition techniques, and a broad analytical toolkit for surface characterization, combined with the ability to troubleshoot chemistry performance in the context of an integrated diagnostic device.

Requirements

Experience in developing functional surfaces for biomolecular applications, ultra-low fouling surfaces, polymer thin-films, hydrogel networks.
Working knowledge of nucleic acid chemistry and how surface properties affect hybridization thermodynamics, kinetics, etc.
Surface deposition/patterning methods (PE-CVD, CVD, spin/dip/spray coating, plasma activation/etching, and photolithographic, or inkjet-based patterning.)
Experience working with electrode surfaces and materials (e.g., gold, platinum, carbon, ITO) and/or electrochemical platforms.
Experience with a wide range of substrate materials, including glass, silicon/silicon-based substrates, metal/metal-oxide, polymers/plastics, and patterned/micro-structured or micro-fabricated surfaces.
Strong DOE, statistical analysis, and data interpretation skills.
Solid empirical knowledge of bioconjugations in the context of microarrays and biointerfaces.
Hands-on experience with analytical surface characterization methods: Contact angle goniometry / surface energy analysis, X-ray photoelectron spectroscopy (XPS), Atomic force microscopy (AFM), Scanning electron microscopy (SEM) / SEM-EDS, Ellipsometry (film thickness/uniformity), Fourier-transform infrared spectroscopy (FTIR, incl. ATR-FTIR), Quartz crystal microbalance (QCM-D), Profilometry (surface roughness/topography), Electrochemical impedance spectroscopy (EIS) / cyclic voltammetry (CV), Fluorescence-based surface density/uniformity assays, Zeta potential & surface charge characterization, Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS).
Excellent written and verbal communication skills; ability to present technical results to cross-functional and leadership audiences.
Familiarity with QC method development for surface characterization.

Nice To Haves

Direct experience developing surface chemistry for NGS flow cells, IVD consumables, or microarray substrates in a regulated IVD or medical device environment.
Experience with design controls (21 CFR 820.30 / ISO 13485) and transfer of chemistry/processes to manufacturing.
Experience with cleanroom processes and semiconductor-adjacent fabrication techniques.
Familiarity with biosensor or point-of-care diagnostic platform development.

Responsibilities

Design, synthesize, and optimize surface chemistries (hydrogel, silane, self-assembled monolayers, brush polymer surfaces) for oligonucleotide/probe immobilization, amplification, and hybridization chemistries on next-generation sequencing (NGS), and molecular diagnostic (IVD) platforms.
Develop and optimize surface functionalization processes on diverse substrate materials — glass, silicon, silicon nitride, metals/metal oxides, noble-metal electrodes, polymers, and patterned/micro-structured surfaces.
Lead development and scale-up of surface deposition and patterning processes, including PE-CVD, CVD, spin-coating, dip-coating, spray-coating, vapor-phase deposition, plasma treatment/activation, and photolithographic/printed patterning methods.
Characterize surface chemistry performance and quality using a broad suite of analytical techniques, correlating physicochemical properties to assay performance (signal, specificity, uniformity, density, non-specific binding).
Work closely with electrode-based platform on surface modification of working/reference/counter electrodes and evaluation of electrochemical performance.
Collaborate cross-functionally with Assay Development, Reagent Chemistry, Device/Instrument Engineering, Manufacturing, and Quality/Regulatory teams to transition surface chemistry processes from R&D through pilot scale-up and into IVD manufacturing under design control.
Design and execute DOEs to optimize coating uniformity, reproducibility, shelf-life/stability, and lot-to-lot consistency; support root cause investigations and CAPAs related to surface chemistry performance.
Author and maintain technical reports, protocols, batch records, DHF/design control documentation, and contribute to regulatory submissions (e.g., FDA 510(k)/PMA, CE-IVDR) as needed.
Maintain awareness of literature and emerging technologies in surface chemistry, biofunctionalization, and diagnostic surface engineering; evaluate new materials/methods for potential adoption.
Mentor junior scientists and associates; may manage or direct the work of research associates.
Support IP strategy, including invention disclosures and patent support.
Contribute to troubleshooting surface performance issues and root-cause analysis.