Sr. Software Engineer - Full Stack

Personalis, Inc•Fremont, CA

1d•$150,000 - $175,000•Hybrid

About The Position

Personalis, Inc. is a leader in advanced genomics for precision oncology. NeXT Personal is an ultra-sensitive, tumor-informed, WGS-based liquid biopsy assay designed to detect minimal residual disease (MRD) and cancer recurrence. It leverages whole-genome sequencing of a patient's tumor and matched normal samples to create personalized panel of up to 1,800 somatic variants, enabling the detection of circulating tumor DNA (ctDNA) at very low levels (down to ~1-3 PPM) in blood samples. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale, and efficiency. Personalis is based in Fremont, California. Summary: You are expected to work with a highly talented staff of diverse expertise to clarify requirements, develop next generation software that will assist our comprehensive end-to-end human genome sequencing and analysis products. This position will enrich your experience in all phases of the software development lifecycle allowing you to simplify, invent, build and engineer best in class products.

Requirements

Bachelor’s degree or higher in Computer Science, Computer Engineering, or a related technical field.
5+ years of professional experience in software development, including development of user-facing and enterprise-grade applications.
Strong proficiency in Java (Spring Boot) and ReactJS.
Experience with modern web standards and technologies, including ES6, HTML5, and CSS3.
Solid understanding user experience principles and web application design best practices.
Experience with full-stack development, including web protocols and web server optimization techniques.
Familiarity with microservices architecture and containerization technologies such as Docker and Kubernetes.
Experience working in fast-paced environments and delivering high-impact solutions within defined timelines.
Strong communication and interpersonal skills, with the ability to collaborate effectively across cross-functional teams.

Nice To Haves

Prior experience in biotech, healthcare, or genomics environments is a plus.

Responsibilities

Architect, design, and modernize application software including dashboards, workflow management systems, reporting platforms, and web portals.
Design and develop highly robust, scalable, and user-centric software systems supporting sample processing, order management, and report delivery.
Automate operational workflows to reduce manual processes and enhance system stability.
Design, develop, and maintain system integration interfaces for internal platforms and external partners, supporting healthcare data exchange standards such as HL7 and FHIR, and lead technical discussions to define interface contracts and implementation strategies.
Develop backend services using Java and Python, and build user-facing applications using ReactJS and modern web technologies.
Implement and manage containerized deployments using Docker and Kubernetes, and build and maintain CI/CD pipelines using Jenkins to support automated testing and deployment across on-premise and AWS environments.
Identify system bottlenecks, conduct code reviews, and implement architectural improvements to support growing operational demands.
Provide production support, perform root cause analysis, and drive continuous system enhancements.