Sr Scientist

Amgen•Thousand Oaks, CA

About The Position

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Sr Scientist What you will do Let’s do this. Let’s change the world. We are seeking a motivated Senior Scientist in mass spectrometry–based proteomics to join our talented and collaborative team in Thousand Oaks, CA. In this vital role, you will deliver critical insights to support target identification and drug discovery, while advancing innovative proteomics platform technologies. You will contribute to both pipeline advancement and screening platform innovation by developing and implementing cutting-edge, high-throughput proteomics approaches. This includes executing automated sample preparation and mass spectrometry analyses across a range of assays, as well as designing, optimizing, and continuously enhancing next-generation screening workflows and analytical platforms. This role requires hands-on experience operating and troubleshooting high-throughput mass spectrometry systems. Your work will play a key role in enabling innovative drug screening strategies, accelerating discovery efforts, and strengthening pipeline support.

Requirements

Doctorate degree (PhD, PharmD, or MD) with relevant experience OR Master’s degree and 4 years of directly related experience OR Bachelor’s degree and 6 years of directly related experience

Nice To Haves

Doctorate degree in proteomics, chemoproteomics, biochemistry, chemistry, or a related discipline
Strong track record in developing mass spectrometry–based proteomics assays, operating advanced platforms (e.g., Orbitrap Astral), and analyzing proteomics data
Experience with sample preparation miniaturization and automation platforms
3+ years of experience in the biotech or pharmaceutical industry
Demonstrated innovation in assay, method, or platform development
Strong quantitative and computational expertise in high-dimensional proteomics data analysis
Ability to work effectively in a highly integrated, collaborative team environment, with excellent organizational, verbal, and written communication skills, and a proven track record of producing reliable and reproducible results.
Knowledge of targeted protein degradation or E3 ligase biology is a plus

Responsibilities

Design, develop, and optimize high-throughput mass spectrometry–based proteomics workflows and screening platforms to accelerate drug discovery
Execute automated sample preparation and LC-MS/MS analysis across a broad range of high-throughput proteomics assays
Collaborate closely with chemistry, biology, and disease area teams as a technical and scientific subject matter expert, contributing to data-driven decision-making
Perform data analysis and generate insights into mechanism of action, target engagement, and selectivity using proteomics approaches
Present research findings at internal and external meetings and effectively communicate plans, results, and analyses to cross-functional teams
Maintain accurate and organized documentation of experiments, protocols, and analyses

Benefits

health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities
A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models where possible

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