Sr. Scientist, Toxicology

Legend Biotech US•Philadelphia, PA

2h•$127,313 - $167,099•Hybrid

About The Position

Legend Biotech is seeking a Sr. Scientist, Toxicology to support nonclinical development and safety assessment across cell and gene therapy programs. This individual will contribute to nonclinical strategy from discovery through IND-enabling development and support regulatory submissions for innovative advanced therapies. The role requires scientific expertise in toxicology, a foundation in pharmacology, understanding of regulatory expectations, and the ability to work effectively across cross-functional teams in a fast-paced biotech environment.

Requirements

Ph.D., DVM, PharmD, or equivalent degree in Toxicology, Pharmacology, Immunology, or a related discipline.
Minimum of 5 years of experience in nonclinical toxicology or a related field within biotechnology or pharmaceutical R&D, with working knowledge of pharmacology principles.
Experience supporting cell therapy, gene therapy, biologics, or other advanced therapeutic platforms preferred.
Working knowledge of GLP toxicology studies, nonclinical pharmacology studies, CRO management, and regulatory expectations for nonclinical development.
Experience contributing to IND/CTA-enabling packages and global regulatory submissions is highly desirable.
Understanding of FDA, EMA, and ICH regulations pertaining to toxicology and cell and gene therapy development.
Scientific writing, communication, and presentation skills.
Ability to work independently while thriving in a collaborative, matrixed team environment.

Responsibilities

Support toxicology activities for discovery and development-stage cell and gene therapy programs.
Design, monitor, interpret, and report nonclinical safety, pharmacology, biodistribution, and pharmacokinetic studies.
Support integrated interpretation of toxicology and pharmacology data to enable candidate selection, risk assessment, and program progression.
Contribute to study strategy and execution at CROs, including protocol review, study monitoring, data interpretation, and final report review.
Partner closely with Pharmacology, CMC, Clinical, Regulatory Affairs, and Program Management teams to advance development programs.
Support preparation of regulatory documents, including briefing packages, pre-IND/IND submissions, investigator brochures, and responses to health authority questions.
Contribute to safety risk assessments related to target biology, exaggerated pharmacology, off-target effects, immunogenicity, genome-related risks, and long-term safety.
Interpret complex nonclinical datasets and communicate key findings and recommendations clearly to internal stakeholders.
Stay current with scientific and regulatory advances relevant to toxicology, pharmacology, and cell and gene therapy development.
Support in vivo pharmacology activities, when needed, through integrated assessment of efficacy, disposition, and safety findings.

Benefits

Medical, dental, and vision insurance
401(k) retirement plan with a company match that vests fully on day one
Eight (8) weeks of paid parental leave after just three (3) months of employment
Paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays
Flexible spending and health savings accounts
Life and AD&D insurance
Short- and long-term disability coverage
Legal assistance
Supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance
Voluntary commuter benefits
Family planning and care resources
Well-being initiatives
Peer-to-peer recognition programs