Sr Scientist, Structural Chemistry

Gilead Sciences•Foster City, CA

19h

About The Position

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Requirements

PhD in Structural Biology or related field with postdoctoral training in solving atomic resolution structures of macromolecular complexes
Minimum of 3 years of relevant experience in structural biology, preferably including biopharmaceutical industry experience

Nice To Haves

Extensive experience in single-particle cryo-EM, including grid preparation, optimization, data acquisition, processing, 3D reconstruction, and model building
Hands-on experience in recombinant protein construct design, expression, purification, and characterization
Excellent communication, collaboration, and interpersonal skills in a matrixed team environment
Strong organizational skills with the ability to manage multiple projects independently

Responsibilities

Apply cryo-EM and/or X-ray crystallography to determine high-resolution structures of proteins and macromolecular complexes relevant to drug discovery
Conduct cryo-EM workflows including grid preparation, data collection, image processing, 3D reconstruction, and model building
Collaborate closely with cross-functional teams to integrate structural insights into medicinal chemistry and biologics design efforts including hit validation and hit-to-lead optimization.
Contribute to the operation, optimization, and maintenance of cryo-EM instrumentation and workflows
Present results clearly to internal project teams and contribute to scientific publications and reports
Independently manage multiple projects in a fast-paced environment and deliver impactful results