Sr. Scientist, Spatial Biology

Noetik•South San Francisco, CA

1d•Hybrid

About The Position

In this role, we are seeking a highly motivated and detail-oriented Senior Scientist to join our team at the frontier of spatial biology and AI, driving hands on execution, protocol development, and quality standards for spatial biology experiments on human tissue samples in a lab built to fuel next-generation AI models. The ideal candidate will have deep hands-on experience with in situ hybridization & proteomics techniques, spatial data analysis and demonstrate strong troubleshooting, mentorship, and organizational skills. This is an exciting opportunity to contribute to a multidisciplinary laboratory environment at the interface between Spatial Biology and AI model generation. As we scale up our data generation engine, this role is focused on driving impact through day-to-day execution, troubleshooting, and quality enforcement across a high volume of runs.

Requirements

PhD in molecular biology, genomics, cell biology, biomedical engineering, or a related field.
2-5+ years of industry hands-on experience with spatial transcriptomics (CosMx, Xenium, MERFISH…); direct CosMx experience strongly preferred.
Experience with spatial proteomics platforms (e.g., CosMx Protein, Akoya PhenoCycler, Lunaphore..) and immunofluorescence panel design are highly desirable.
Proven ability to independently troubleshoot wet-lab and imaging-based assay failures, tracing issues back to root cause.
Solid knowledge of spatial transcriptomics data QC metrics: transcript count distributions, segmentation quality, dropout/housekeeping-gene diagnostics, batch effects, and spatial artifacts.
Comfortable enforcing standards across a team that includes both junior and more senior colleagues — this role requires leadership as well as technical skill.
Excellent organizational, communication (oral and written), and documentation skills.
Computational fluency.

Nice To Haves

Familiarity with cancer tissue biology and identity marker panels.
Proficiency with Python or R for data analysis.
Prior experience mentoring or informally leading junior lab staff.

Responsibilities

Independently plan, perform and troubleshoot spatial biology experiments on human tissue samples.
Establish and enforce data quality standards across the team's experiments and analysis pipelines.
Mentor and train team members on technique, rigor, and quality judgment.
Collaborate closely with cross-functional teams including Histology, and Scientific Operations to ensure seamless project execution.
Actively participate in lab team meetings, fostering a collaborative and innovation-driven culture.
Lead cross-functional projects with Engineering and ML Team members to design the next generation of data for AI model training.

Benefits

Generous health, dental, and vision insurance, with premiums fully covered for both employees and their dependents (depending on your plan choice).
Comprehensive and accessible coverage, featuring modern care platforms like OneMedical, Midi Health, Spring Health, and XP Health.
HSA and FSA accounts.
Dependent care savings.
EAP.
Resources for mental health (Rula).
Health care navigation and advocacy (Rightway).
Flexible PTO.
Nine paid holidays.
Synchronized breaks: two full-week company breaks (the first week of July and the last week of December), plus the Friday after Thanksgiving.
Competitive base salary.
Stock options.
401(k) plan with an employer match.
Fully-covered disability, life and AD&D insurance.
Generous parental leave.
Financial and lifestyle tools, including SoFi, Multiply Mortgage.
Optional programs for pet insurance, legal services, and identity theft protection.