Sr Scientist/Principal Scientist - Genomics Sciences

Lilly • Boston, MA

4d • $71,250 - $187,000 • Onsite

About The Position

The Genomic Sciences team within Lilly Genetic Medicine/RNA Therapeutics is seeking a senior experimental genomics expert to lead and execute genomics assays in support of the discovery and development of RNA medicines. This role is embedded in a high-throughput genomics screening environment that generates decisional data for siRNA and antisense oligonucleotide programs across the LGM portfolio. The successful candidate will be a hands-on experimentalist with strong technical skills in next-generation sequencing (NGS), a commitment to rigorous sample management and documentation, and a desire to contribute meaningfully to the advancement of genetic medicines.

Requirements

• Bachelor’s degree in genomics, molecular biology, biochemistry, genetics, or a related discipline with a minimum of 3+ years of relevant laboratory experience; OR Master’s degree in genomics, molecular biology, biochemistry, genetics, or a related discipline with a minimum of 1+ years of relevant laboratory experience
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1

Nice To Haves

• Demonstrated hands-on experience with NGS library preparation, quality control (Qubit, TapeStation/Bioanalyzer, qPCR-based quantification), and sequencer operation
• Strong organizational skills with meticulous attention to sample management, documentation, and experimental reproducibility
• Ability to work effectively in a fast-paced, team-oriented research environment generating high-quality decisional data at scale
• Experience with high-throughput or pooled screening workflows in a pharmaceutical or genomics core environment
• Experience with singe cell genomics or spatial transcriptomics data
• Familiarity with RNA therapeutics biology (siRNA, ASO) and associated transcriptomic readouts
• Bioinformatics experience including comfort with command-line tools, scripting (R, Python), and/or analysis of NGS data (alignment, QC metrics, differential expression)
• Experience with automation platforms (e.g., Hamilton, Beckman) for library preparation or sample handling
• Track record of method development or assay optimization in a research or development setting
• Experience using and developing ELN based documentation tools.

Responsibilities

• Execute and optimize NGS library preparation workflows (e.g., 3’ RNA-seq, mRNA-seq, etc.) across targeted and large-scale screening campaigns, maintaining high quality and throughput
• Track, document, and QC samples through all stages of assay development
• Develop, troubleshoot, and refine genomics assay protocols to meet evolving program needs, including new library chemistries, multiplexing strategies, and sample input optimization
• Maintain impeccable sample tracking, chain-of-custody documentation, and electronic lab notebook records in compliance with Lilly quality standards
• Collaborate closely with computational genomics, medicinal chemistry, and biology colleagues to ensure experimental designs generate robust, interpretable, and decisional data
• Participate actively in cross-functional project teams, contributing scientific perspective on assay design, data interpretation, and experimental prioritization
• Support lab infrastructure including reagent inventory, equipment maintenance, and continuous improvement of standard operating procedures

Benefits

• company bonus (depending, in part, on company and individual performance)
• company-sponsored 401(k)
• pension
• vacation benefits
• medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

What This Job Offers

• Job Type: Full-time
• Career Level: Senior