Sr. Scientist - Mass Spec Development

KCAS Bio • Kansas City, KS

1d

About The Position

Performing critical work that impacts our industry and our world’s health while problem solving and innovating in the field – that is what Sr. Scientists at KCAS Bio get to do every day. If that gets you excited too, then maybe working as a Sr. Scientist at KCAS Bio is the role for you. When you work as a Sr Scientist in the Mass Spec Bioanalysis Development group at KCAS, you get to further our mission by leveraging your knowledge in bioanalytical and scientific principles to be responsible carrying out all aspects of a study, from study setup through reporting, as well as development. You will also utilize your strong base in scientific principles/theories to assess data integrity and troubleshoot when necessary. Our Mass Spec Bioanalysis Development team uses LCMS (Liquid Chromatography Mass Spectrometry) techniques to conduct sophisticated sample preparation to meet bioanalytical needs for drug discovery, preclinical, and clinical studies, including bioanalysis of drugs and metabolites, biomarkers, and active endogenous compounds in biological fluids and tissues. In this role, we will rely on you to: Design and execute all phases of assigned projects including sample preparation (extractions, enrichments/affinity capture, digestions), method development and qualification for LCMS, troubleshooting, data analysis, and report generation. Act as lead scientist, help to design experiments, provide work instructions and technical training to more junior scientific staff in daily activities. Be responsible for all client communication related to study conduct. Interacts with QAU to resolve identified audit issues and is accountable for continuous quality management in assigned studies. Have final authority for sample identification, including clinical site discrepancies and/or client. Be responsible for timeline adherence and communication of status to management as required. Ensure compliance of study activities with pertinent portion of study protocol, SOPs & regulatory requirements Be able to setup and change instrument configurations for various LCMS methods. Prepare data summaries for senior scientists to aid in client updates. Act as a technical expert for all aspects of process design and problem solving. Perform all aspects of the job in a way that supports company brand and supports company mission, vision, and values.

Requirements

• Bachelor’s, Master’s, or PhD in Chemistry, Biochemistry or chemical/biochemical engineering, or related field with at least 5 years of experience with LC-MS/MS
• 2-3 years of experience in a Principal Investigator role
• Bioanalytical sample preparation, Quantitative LC-MS/MS, and multi-dimensional chromatography

Nice To Haves

• Experience with proteins and peptides as well as small molecule biomarkers is preferred
• Experience with Reversed Phase and Hilic chromatography at the analytical and micro/nano flow rates or protein digestions and immunoaffinity enrichments (hybrid LCMS) is a plus

Responsibilities

• Design and execute all phases of assigned projects including sample preparation (extractions, enrichments/affinity capture, digestions), method development and qualification for LCMS, troubleshooting, data analysis, and report generation.
• Act as lead scientist, help to design experiments, provide work instructions and technical training to more junior scientific staff in daily activities.
• Be responsible for all client communication related to study conduct.
• Interacts with QAU to resolve identified audit issues and is accountable for continuous quality management in assigned studies.
• Have final authority for sample identification, including clinical site discrepancies and/or client.
• Be responsible for timeline adherence and communication of status to management as required.
• Ensure compliance of study activities with pertinent portion of study protocol, SOPs & regulatory requirements
• Be able to setup and change instrument configurations for various LCMS methods.
• Prepare data summaries for senior scientists to aid in client updates.
• Act as a technical expert for all aspects of process design and problem solving.
• Perform all aspects of the job in a way that supports company brand and supports company mission, vision, and values.

Benefits

• At KCAS Bio, you will enjoy company sponsored events like food trucks, family days and spirit days.
• You will grow in your career with KCAS University.
• You will be able to connect with like-minded employees to further KCAS Bio's approach to key areas such as wellness, inclusion, and community outreach.
• You will engage as an owner in our stock ownership program.
• You will have access to the latest technology.
• And you will be able to invest in the community with paid time off to volunteer.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 101-250 employees