Sr Scientist, Inflammation Biomarkers and Translational Research
About The Position
At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.
Requirements
- PhD or MD/PhD in Immunology, Inflammation Biology, Translational Medicine, or related discipline.
- Typically, 5–8+ years of relevant post‑doctoral and industry experience with demonstrated leadership of biomarker strategies for clinical programs.
- Strong record of scientific contributions, including high profile publications and/or patents.
- Deep understanding of human immunology, inflammation, and/or fibrotic disease biology with hands-on mindset balanced with a strategic perspective.
- Proactive problem-solver with proven experience designing and implementing clinical biomarker strategies, including assay validation and outsourcing.
- A clear and effective communicator with the ability to influence across functions, with experience contributing to regulatory and external‑facing documents.
Nice To Haves
- Expertise in liver and/or gut biology, including fibrotic mechanisms, as demonstrated by high profile publications in this space.
- Demonstrated ability to lead biomarker strategy for Phase I–III clinical trials and work within regulated development environments.
- Prior experience interacting with health authorities on biomarker related topics.
- Familiarity with high dimensional platforms (flow/mass cytometry, single‑cell, spatial, digital pathology).
- Working knowledge of data analysis tools (e.g., R, Python) for biomarker QC and interpretation.
Responsibilities
- Lead the end-to-end biomarker strategy for one or more clinical programs, from early translational research through Phase I-III and registrational studies, aligned with program objectives and regulatory expectations.
- Define and implement fit for purpose pharmacodynamic (target engagement, pathway modulation, and pathophysiology changes), MOA, prognostic, predictive, and disease‑monitoring biomarkers, including assay qualification, validation, and transfer to CROs.
- Serve as the biomarker lead for cross-functional program teams, providing scientific direction, risk assessment, and contingency planning.
- Support inspection-ready biomarker operations, including CRO oversight, vendor management, and data quality assurance.
- Design and oversee human-relevant translational studies using primary human samples.
- Lead responder vs. nonresponder analyses, pathway interrogation, and reverse‑translation efforts using clinical and real-world data.
- Integrate multi-omic, spatial, imaging, and clinical datasets to generate actionable insights and inform program decisions.
- Author and review clinical biomarker sections for protocols, IBs, SAPs, and regulatory documents.
- Partner with Clinical, Biostats, and Regulatory to ensure biomarker strategies are aligned with registrational and post‑marketing objectives.
- Present clinical biomarker data at conferences and investigator meetings, and author biomarker research focused scientific publications.
- Contribute to and participate in health authority interactions (e.g., FDA, EMA), including briefing documents, responses, and meetings, representing biomarker and translational strategy.
- Engage with external collaborators, consortia, and KOLs, and represent the organization in scientific and advisory forums as appropriate.
- Provide matrix leadership across functions; mentor junior scientists and contribute to scientific capability building within the group.
- Help shape portfolio-level biomarker strategy, standards, and innovation initiatives.
- Influence decision making through clear scientific communication, data‑driven recommendations, and strong stakeholder engagement.
Benefits
- company-sponsored medical, dental, vision, and life insurance plans.
- discretionary annual bonus
- discretionary stock-based long-term incentives (eligibility may vary based on role)
- paid time off
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
