Sr. Scientist, DMPK

Neurocrine Biosciences • San Diego, CA

8d

About The Position

We are looking for a collaborative and highly motivated senior scientist to join our biotransformation and metabolism group. The primary role will be to support in vitro and in vivo metabolite identification for multiple discovery and development projects. The ideal candidate should provide subject matter expertise in enzymology and small molecule or large molecule biotransformation/metabolite identification. The candidate will also have the opportunity to represent preclinical development on research and development teams and regularly interface with internal and external colleagues to ensure timely and accurate dissemination of ADME findings.

Requirements

• PhD in Biochemistry, Drug Metabolism, or closely related discipline with 2+ years of experience in the industrial discovery and development of small and large molecular therapeutics OR MS with 5+ years of experience OR BS with 10+ years of experience
• Expertise and working knowledge of biotransformation of small molecules, enzymology and LC-MS/MS methodology
• Experience with handling of biological samples containing radioactivity used in ADME studies
• Ability to balance multiple projects and handle competing responsibilities
• Demonstrate strong communication skills with the ability to integrate diverse perspectives, deliver critical messaging, and influence leaders/key partners
• Collaborative team behaviors and aspiration to build and sustain relationships with R&D customers and the wider scientific community

Nice To Haves

• Experience with isolation of metabolite and NMR a plus

Responsibilities

• Independently conduct in vitro and in vivo metabolite identification studies including (but not limited to) preparing and analyzing samples for LC-MS/MS analysis, processing data and interpretation of data to understand metabolic pathways
• Develop and implement suitable analytical LC separation methods and troubleshooting analytical issues with minimal supervision
• Develop and optimize MS methods to obtain structural characterization of metabolites of interest
• Radioanalysis (14C, 3H, etc.,) and radio-profiling of in vitro and in vivo biological samples for quantitation and identification of metabolites
• Perform routine instrument maintenance, repair and may troubleshoot complex instrument issues
• Writing protocols and reports, compiling, analyzing, and interpreting data
• Ensuring timely delivery of results in line with project schedules
• Prepare data summaries and present results to peers, colleagues, project team and leadership teams
• Possess excellent written and verbal technical communication skills and the demonstrated ability to lead, guide and influence teams in decision making

Benefits

• retirement savings plan (with company match)
• paid vacation, holiday and personal days
• paid caregiver/parental and medical leave
• health benefits to include medical, prescription drug, dental and vision coverage

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree