(Scientist) Sr. Scientist, Cardiovascular and Metabolic Disease

Flagship Pioneering•Cambridge, MA

22h

About The Position

We are seeking an exceptional Scientist or Senior Scientist to lead and support discovery efforts in projects in Cardiovascular and Metabolic Disease. This role will contribute to shaping our pipeline, bringing scientific leadership and creativity to target validation, drug discovery translational biology. The ideal candidate brings a strong foundation in cardiovascular or metabolic disease biology, a passion for novel biology, and experience designing and executing mechanistic and pharmacology studies that bridge in vitro and in vivo models. This is a high-impact, cross-functional role with the opportunity to work closely with platform scientists, computational biologists, and drug discovery teams to identify and advance novel targets into drug development.

Requirements

Ph.D. in physiology, pharmacology, cell biology, or a related field
2+ years (Scientist) or 5+ years (Senior Scientist) of relevant postdoctoral or industry experience
Experience working in biotech or pharma
Experience with cellular assays and in vitro pharmacology assays
Hands-on expertise in cellular/molecular biology techniques (e.g., CRISPR, ELISA, qPCR, Western blotting, RNAseq) and assay development
Strong track record of scientific contributions (publications, patents, presentations)
Excellent communication, collaboration, and organizational skills in a fast-paced, team-oriented environment

Nice To Haves

Postdoctoral training or industry experience strongly preferred
Deep understanding of disease mechanisms and translational models in one or more areas: obesity, type 2 diabetes, atherosclerosis, heart failure, MASH, lipid metabolism or vascular disease
Ability to integrate multi-omic or genetic data into experimental design
Familiarity with target identification and validation processes
Experience with human tissue samples, iPSC-derived systems, or organoid models is a plus

Responsibilities

Drive discovery research in cardiovascular and/or metabolic disease areas by designing, executing, and interpreting mechanistic studies using state-of-the-art models and technologies
Lead target validation efforts informed by proteomic and computational insights; develop hypotheses and prioritize targets with high translational potential
Collaborate with computational biology and proteomics teams to interpret large-scale datasets (e.g., proteomic, transcriptomic, genetic) and generate novel biological insights
Design and oversee in vitro and in vivo models of disease to support target biology, candidate selection, biomarker development, and proof-of-concept studies
Contribute to building and refining the company’s therapeutic strategy in CVD/metabolic disease
Communicate findings clearly and effectively in cross-functional team meetings, external collaborations, and presentations to leadership
Support or lead external academic and industry collaborations