Sr GMAL, Obesity (GLP-1 / GCG RA)

AstraZeneca • Boston, MA

3d • $243,586 - $365,379 • Onsite

About The Position

AstraZeneca is advancing a tailored approach to Obesity and Weight Management, uniting science, medical and commercial excellence to deliver durable outcomes, reduce cardiometabolic risk and protect organs. Our pipeline is moving with purpose and includes next generation oral and injectable therapies that prioritises tolerability, durability and quality of life. As the Senior Global Medical Affairs Leader for Obesity and the once-weekly GLP-1/GCG RA, you'll play a pivotal role in shaping the future of obesity care. This is your chance to use your expertise to make a real impact on patients' lives. Join us in our mission to transform the patient journey, from prevention to diagnosis, and beyond.

In this dynamic role, you'll be responsible for providing medical leadership across the entire product lifecycle. You'll advise on Research & Development investment decisions, lead pre-launch scientific efforts, and accelerate evidence-based healthcare changes in the real world. Your networking and influencing skills will be key as you facilitate cross-functional collaboration and drive innovation. Are you ready to take on this challenge?

Reporting to the Medical Head of Weight Management for the Injectables Franchise, the Senior GMAL is a highly experienced Medical Affairs leader with proven vision and impact. The main responsibility will be for the once-weekly GLP-1/GCG RA for obesity with multi-organ complications. This individual develops and leads bold medical strategies within the obesity and cardiorenal-metabolic outcomes therapy area (specifically MASH, heart failure and CKD), expertly guiding cross-functional and cross-regional teams to deliver and exceed ambitious goals. The Senior GMAL’s influence is enterprise-wide—shaping global medical agendas through Global Medical Team, Global Product Team, and Disease Area Team leadership, and deep partnership with Medical and Commercial functions in markets and regions worldwide. This role demands a leader who champions innovative, disruptive thinking—identifies and shapes breakthrough opportunities, reimagines market dynamics, and accelerates high-impact evidence generation and medical change initiatives. The Senior GMAL navigates and transforms health systems, leverages digital and advanced analytics, drives stakeholder engagement, and ensures AstraZeneca’s science leads externally and internally through world-class medical evidence and strategic partnerships.

Requirements

• Doctoral-level degree (MD, PhD, PharmD) or Master’s degree with at least 5 years of experience in the pharmaceutical industry (Medical, Marketing, R&D, Market Access), or extensive experience within a health system (clinical, pharmacy, pathway design, etc.).
• Demonstrated leadership in complex, global healthcare environments, including leading franchise/TA business in key markets, driving brand performance, and managing large, diverse teams.
• Significant expertise and strategic insight into healthcare system pathways, regulatory landscapes, market-shaping, and external stakeholder engagement.
• Strong track record of internal and external network building, collaboration across geographies and matrix teams, and effective mentoring of junior colleagues or peers.
• Digital proficiency, leveraging digital health tools and data platforms to advance evidence generation and communication.
• Deep understanding of patient care pathways, evolving treatment protocols, scientific literature, and contemporary approaches to healthcare transformation.
• Proven ability to guide, influence, and align diverse stakeholders—including thought leaders, regulatory bodies, patient groups, and payer organisations.

Nice To Haves

• Clinical experience in obesity, PCP, heart failure and/or CKD
• Experience with the USA health care system
• Recognised expertise in the relevant or related therapeutic area, often evidenced by a history of clinical practice, research leadership, or significant external engagement.
• Advanced experience designing, leading, and interpreting clinical research programs, including pivotal clinical trials (Ph2–Ph4), practice-changing RWE studies, and implementation of innovative evidence generation approaches.
• Broad experience beyond Medical Affairs; for example, prior roles in Marketing, R&D, or Market Access.
• Long-standing relationships with global KOLs, societies, regulators, digital health partners, and innovative healthcare organisations.
• Track record of launching new products or indications in multiple, diverse markets (e.g., US, China, EU), and successfully developing and executing global medical strategies.

Responsibilities

• Provide medical leadership across the entire product lifecycle.
• Advise on Research & Development investment decisions.
• Lead pre-launch scientific efforts.
• Accelerate evidence-based healthcare changes in the real world.
• Facilitate cross-functional collaboration and drive innovation.
• Develop and lead bold medical strategies within the obesity and cardiorenal-metabolic outcomes therapy area (specifically MASH, heart failure and CKD).
• Expertly guide cross-functional and cross-regional teams to deliver and exceed ambitious goals.
• Shape global medical agendas through Global Medical Team, Global Product Team, and Disease Area Team leadership.
• Deep partnership with Medical and Commercial functions in markets and regions worldwide.
• Identify and shape breakthrough opportunities, reimagine market dynamics, and accelerate high-impact evidence generation and medical change initiatives.
• Navigate and transform health systems.
• Leverage digital and advanced analytics.
• Drive stakeholder engagement.
• Ensure AstraZeneca’s science leads externally and internally through world-class medical evidence and strategic partnerships.
• Design and lead the implementation of product and disease area strategies, as well as ambitious practice change initiatives, at a global level.
• Consistently deliver innovative, disruptive solutions to shape markets, challenge status quo thinking, and use digital proficiency to identify data-driven opportunities, preparing for launch and life cycle management.
• Own the evidence generation strategy—demonstrating advanced experience in clinical research, interventional trials (Phases 2–4), and real-world evidence (RWE) programs.
• Shape and drive groundbreaking clinical trials, registries, and RWE studies aligned with brand, access, and practice-changing objectives.
• Guide the optimisation, communication, and strategic roll-out of data across scientific platforms, ensuring AstraZeneca delivers differentiated evidence that supports the needs of regulatory, payer, and healthcare providers.
• Blend scientific expertise with strong digital acumen.
• Leverage digital health tools, advanced analytics, and data platforms to transform evidence communication, personalize stakeholder engagement, and enhance patient outcomes.
• Craft compelling narratives, drive digital dissemination of evidence, and ensure accurate, impactful, and compliant scientific communications.
• Build and sustain powerful relationships across the healthcare ecosystem—including global and regional KOLs, professional societies, regulators, payers, patient organizations, digital innovators, and health systems.
• Mobilize support for medical strategy, evidence generation, and healthcare change initiatives.
• Mentor and guide cross-functional teams, championing scientific leadership and strategic collaboration.
• Ensure clinical trial and evidence generation initiatives are designed for both scientific and regulatory success.
• Anticipate evolving regulatory and payer requirements for evidence, ensuring high quality, compliant data generation and communication at every stage.

Benefits

• Eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles.
• Qualified retirement programs
• Paid time off (i.e., vacation, holiday, and leaves)
• Health, dental, and vision coverage in accordance with the terms of the applicable plans.
• Relocation support provided

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree