Sr. Associate Scientist, Translational Pharmacology

Bristol Myers Squibb • San Diego, CA

5d • Onsite

About The Position

This laboratory-based role presents an exciting opportunity to advance novel radiopharmaceutical therapies from bench to bedside. The successful candidate will be responsible for conducting in vivo studies using CDX, PDX, and syngeneic mouse models to evaluate tumor growth kinetics, biodistribution, and therapeutic efficacy across various pipeline projects. These studies will include the assessment of radiopharmaceutical agents and other therapeutic modalities. In addition to in vivo work, the candidate will perform in vitro mechanistic experiments to explore translational aspects of treatment response. The ideal candidate will have strong hands-on experience in in vivo and in vitro pharmacology, demonstrate critical thinking, and possess excellent technical problem-solving skills. A collaborative mindset and enthusiasm for working in interdisciplinary teams are essential. This role requires the ability and willingness to work with radioactive isotopes.

Requirements

• BS with 4+ years of experience or MS with 2+ years of experience in in vivo pharmacology, translational research, biology, molecular biology, or a related discipline, with hands-on laboratory experience.
• Hands-on experience with cell culture, tumor cell/fragment implantation, animal handling, surgery, dosing (all routes, with intravenous route required), and necropsy.
• Familiarity and hands-on experience with cell-based assays and molecular biology techniques, viability assays, ELISA, western blot etc.
• Excellent written, oral communication, and presentation skills, with the ability to work in a fast-paced, dynamic, and collaborative environment.
• Strong interpersonal, organizational, and communication skills.
• Familiarity with the drug development process and experience working with interdisciplinary teams.
• Ability to work with radioisotopes, strictly adhering to radiation safety protocols.

Nice To Haves

• Prior experience working on translational or pharmacology projects in an industrial or academic setting is preferred.

Responsibilities

• Design and execute in vivo studies using CDX, PDX, and syngeneic mouse models to evaluate tumor growth kinetics, biodistribution, therapeutic efficacy, and durability of response across various treatment modalities, including radiopharmaceutical agents.
• Perform essential in vivo procedures, including cell culture, tumor cell and PDX fragment implantation, surgical modeling of physiological conditions, intravenous dosing, tumor and body weight monitoring, periodic blood collection and necropsy.
• Independently analyze and interpret experimental data, and present findings at project team meetings, departmental reviews, and company-wide forums.
• Conduct in vitro experiments post-training, including cell viability and cytotoxicity assays, proliferation analysis, mechanistic studies (e.g., apoptosis, DNA damage response), and pathway interrogation using molecular biology techniques.
• Maintain meticulous records of all experimental procedures, data, and observations in accordance with regulatory and internal standards.
• Work with radioactive materials in strict compliance with institutional and federal radiation safety protocols.
• Contribute to experimental design and planning, helping to drive project milestones under tight timelines and dynamic priorities.
• Support translational and in vivo pharmacology efforts under the guidance of project leads, ensuring adherence to animal welfare guidelines and strategic prioritization of studies.
• Collaborate cross-functionally with teams in translational research, medicinal chemistry, and other scientific disciplines to advance pipeline objectives.
• Assist with laboratory operations, including inventory management, equipment maintenance, and compliance documentation.
• Uses AI tools to enhance individual productivity and quality of work

Benefits

• Medical, pharmacy, dental, and vision care.
• BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees))
• 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
• unlimited paid sick time
• up to 2 paid volunteer days per year
• summer hours flexibility
• leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs
• an annual Global Shutdown between Christmas and New Years Day.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level