Software Engineer 2

Personalis, Inc•Fremont, CA

8h•$130,000 - $155,000•Hybrid

About The Position

Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited. Personalis is based in Fremont, California. We are seeking a Software Engineer II to design, develop, and maintain our Laboratory Information Management Systems (LIMS). This role is a key contributor to our engineering team, taking ownership of feature development for both existing systems and new cloud-based platforms. You will work with senior engineers to tackle complex problems and deliver high-quality, scalable solutions that power our laboratory operations in a regulated environment.

Requirements

B.S. degree in Computer Science, Engineering, or a related technical field.
2-5 years of professional software development experience.
Strong proficiency in at least one programming language such as Python or Java.
Proven experience building and deploying applications on AWS.
Solid experience with relational databases (e.g., PostgreSQL, MySQL) and developing REST APIs.
Experience with version control systems (e.g., Github, Bitbucket) and CI/CD concepts.
Excellent problem-solving skills and the ability to work independently on complex tasks.

Nice To Haves

Experience with web frameworks like Flask or FastAPI.
Familiarity with modern JavaScript frameworks (e.g., React, Angular, or Vue.js).
Experience in the life sciences, healthcare, or another regulated industry.
Familiarity with containerization technologies (e.g., Docker).
Exposure to graph databases or NoSQL technologies.

Responsibilities

Design, develop, test, and maintain software systems and features supporting laboratory operations.
Develop and optimize backend services and APIs using Python and/or Java.
Implement solutions using a variety of database technologies, including relational and graph databases.
Take ownership of deploying and maintaining services in our AWS cloud environment.
Actively participate in code reviews, design discussions, and technical documentation to ensure quality and maintainability.
Troubleshoot and resolve complex technical issues in development and production environments.
Collaborate with cross-functional teams to translate business requirements into robust technical solutions.