Senior Systems Engineer

Roche•Santa Clara, CA

30d•$83,900 - $155,700•Onsite

About The Position

Roche Sequencing Solutions at the Santa Clara site is developing new technologies to make genetic testing easy, reliable, and affordable. We are creating technologies and workflows that can be used to improve the lives of people in a wide variety of applications including the timely screening of newborns for diseases and the diagnosis of cancers and infectious diseases. We are seeking a passionate Senior Systems Engineer to join our Systems Development Group to support the Next Generation Sequencing (NGS) products. The candidate is expected to be a hands-on key contributor in the feasibility, development, customer support, and integration phases of end-to-end NGS solutions, according to customer & product requirements, and applicable regulatory and quality standards. This is a highly collaborative team and the Senior Systems Engineer will become an expert on the operation of the Roche Single Molecular Sequencing Platform. As a Senior System Engineer, you will learn how to use the new Roche Single Molecule Sequencing platform and help to develop the final operating protocols. The candidate will help design and perform wet-lab experiments to further develop the sequencing prototype instrument. The candidate will work with his/her manager and team members to interpret the experimental results and design future experiments. The candidate must be self-motivated and able to work well in a multidisciplinary team environment.

Requirements

Bachelor’s in Science, Chemistry, Engineering or related field and a minimum of 2 years of related experience; or an advanced degree in the above related fields with 1 or more years of related experience.
Strong understanding of DNA & Molecular Biology.
Proven hands-on troubleshooting experience and skills in wet bench workflows on NGS platform.
Demonstrated experience working with multidisciplinary teams, i.e. chemistry, hardware, software.
3+ years of hands-on experience with DNA sequencing such as raw sample preparation, nucleic acid extraction, library preparation, and NGS sequencing.
Previous laboratory experience with nucleic acid handling and contamination control.
Experience with statistical tools (e.g. Python/JMP for regression analysis, ANOVA), Design of Experiments methodology, and the application of statistical process control.
Proven hands-on experience with PCR technology.
Demonstrated ability to work well in teams and across scientific disciplines is essential.

Nice To Haves

Experience in implementing workflow on semiconductor-based sensing devices or microfluidic devices.
Experience with prototype instruments or DNA sequencing.
Knowledge in surface chemistry.
Knowledge in all phases of NGS workflow such as nucleic acid chemistry, and primer design technologies for gene targets.
Passionate, self-motivated, and possess a strong desire to acquire on-the-job training.

Responsibilities

Perform a variety of sample prep, library, or sequencing and sequencing related experiments on a daily basis.
Help analyze and interpret the data.
Provide customer support activities such as monitoring runs, documenting and communicating defects, and following escalation paths to resolve customer issues.
Travel to customer sites if needed.
Perform all work using best laboratory practices and maintain a well-organized and concise record of work performed and progress made.
Assist engineers with hardware design through testing subcomponents.
Collaborate to identify opportunities for continuous improvement.
Analyze data, derive conclusions, document findings, write SOPs and prepare reports for sharing within and between R&D groups.
Work independently with limited management direction to drive product development using strong experimental designs.
Set up strong experimental designs while working independently.
Maintain detailed documentation throughout all phases of research and development.
Support our instruments; learn troubleshooting techniques as needed to assist R&D and to support customers.