Senior System Administrator - Genomics
About The Position
BigRio is a Boston-based, remote-first technology consulting firm specializing in AI/ML, data engineering, cloud transformation, genomics platforms, and custom software development. We partner with healthcare, life sciences, biotech, and enterprise organizations to design scalable, secure, and high-performance technology platforms that drive innovation and business growth. At BigRio, we believe strong infrastructure is the backbone of successful digital transformation. We are seeking a Senior System Administrator who is passionate about building resilient, secure, and scalable cloud environments that support mission-critical systems, genomics workloads, and high-impact client engagements. The Senior System Administrator will play a key role in designing, implementing, and maintaining modern cloud infrastructure environments, primarily within Azure and Linux ecosystems. This role requires strong technical expertise, a continuous improvement mindset, and the ability to collaborate effectively across engineering, DevOps, bioinformatics, and client stakeholders. The ideal candidate thrives in fast-paced environments, balances best practices with pragmatism, and is excited to help build infrastructure that supports AI-driven, genomics, and data-intensive platforms.
Requirements
- 5+ years of experience as a System Administrator with a focus on Azure and Linux environments
- Strong understanding of modern infrastructure and cloud best practices
- Proven expertise managing Azure services and resources
- Strong Linux administration skills including shell scripting and system optimization
- Experience working with HPC environments and distributed computing clusters
- Proficiency in automation and scripting (Python, Bash, PowerShell)
- Experience with Infrastructure as Code (Terraform, Ansible, or similar)
- Experience supporting large-scale storage systems and data-intensive workloads
- Experience collaborating with engineering, infrastructure, bioinformatics, and leadership teams
- Strong communication and documentation skills
- Self-motivated with attention to detail and ownership mindset
Nice To Haves
- Bachelor's degree preferred
- Experience with Epic Aura or similar healthcare platforms preferred
- Experience supporting genomics, bioinformatics, or life sciences environments preferred
- Experience working with Illumina sequencing platforms, Illumina Connected Analytics, Illumina BaseSpace, genomics pipelines, or related genomics infrastructure strongly preferred
- Familiarity with genomic data workflows, sequencing data storage, and high-throughput data processing environments
- Experience with Illumina sequencing environments and associated infrastructure
- Exposure to genomics pipelines such as BCL conversion, FASTQ processing, alignment, and variant analysis workflows
- Familiarity with tools and workflows used in bioinformatics environments
- Experience supporting HIPAA-compliant or regulated healthcare/life sciences environments
Responsibilities
- Design, deploy, and manage Azure resources ensuring availability, security, and performance
- Monitor infrastructure with focus on cost optimization and resource efficiency
- Implement and maintain backup, disaster recovery, and business continuity plans
- Perform performance tuning and capacity planning to support scalability
- Support infrastructure for genomics and bioinformatics workloads including large-scale sequencing data environments
- Manage secure storage, transfer, and archival strategies for genomic datasets
- Manage and optimize HPC environments
- Ensure efficient job scheduling and resource allocation
- Support compute-intensive genomics and sequencing analysis pipelines
- Maintain system health, patching, and compliance standards
- Optimize storage and compute performance for high-throughput sequencing workloads
- Develop automation scripts to improve operational efficiency
- Implement Infrastructure as Code (IaC) for scalable deployments
- Support CI/CD workflows and cross-team deployments
- Automate deployment and operational processes for genomics and bioinformatics applications
- Implement security best practices and system hardening
- Maintain compliance across healthcare and life sciences environments
- Support audits and documentation requirements
- Ensure proper handling and protection of sensitive healthcare and genomic data
- Work closely with cross-functional teams across engineering, bioinformatics, and client environments
- Provide technical mentorship to junior team members
- Research and recommend new technologies to improve infrastructure maturity
- Partner with stakeholders to support scalable AI/ML and genomics platforms
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Associate degree
