Senior Staff R&D Informatics Lead

Revolution Medicines•Redwood City, CA

11d•Hybrid

About The Position

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: We are seeking a Sr. Staff R&D Informatics Lead to work as part of a dynamic informatics team solving problems and building software tools across R&D. This is a broad, hands-on role for someone who can move fluidly between product ownership, technical delivery, scientific partnership, business analysis, training, support and execution. As a result, it has the potential to make a significant impact to RevMed’s R&D efforts. You will work with cross-functional stakeholders in Research, Translational Medicine, Quantitative Sciences and related R&D functions to identify high-value informatics opportunities, deploy fit-for-purpose COTS and bespoke software tools, and build practical solutions that improve how scientific and operational work gets done. You will also help plan and implement strategies to streamline software development, ongoing support, contracting, computer system validation, budgeting and portfolio tracking.

Requirements

BS/MS/Ph.D. in Biology, Chemistry or Computer Science.
10+ years of experience developing software tools supporting the drug, vaccine or medical device industries.
Strong understanding of R&D data types, models, standards and analytical workflows in Research, Translational and Clinical groups.
Rare ability to code switch between Biology/Chemistry and computer science and lead efforts that span both domains.
Excellent collaboration and teamwork skills.
development informatics including business analysis and coding.
Ability to define a problem/opportunity, quickly get others on board, lay out a comprehensive but efficient plan of action, and finally implement as quickly as practical.
Experience with AWS (or Azure/GCP) and Databricks.

Nice To Haves

Experience with GLP or GCP regulations and 21 CFR Part 11.
Hands-on experience building pipelines, dashboards and applications using AI-forward development best practices.

Responsibilities

Lead scientific informatics efforts spanning Research to Clinical, including both exploratory and GxP data.
Lead and manage the full range of activities to implement both COTS and bespoke systems.
Own R&D systems; maintain a backlog, track usage, technical debt, spend and the evolving value proposition of each system.
Develop pipelines, data structures and custom apps in AWS and Databricks (either alone or in conjunction with a team) to meet a wide variety of scientific and operational needs in R&D.
Use an AI-forward approach to everything from project management to business analysis to coding and system support while applying appropriate judgement to filter out noise.
Collaborate with scientists on their terms; translate complex informatics and scientific topics seamlessly back and forth across domains.
Lead or Participate in GXP validation activities as necessary.