Senior Software Engineer - Omniverse Development - CDH - Remote

Mayo Clinic•Rochester, MN

2d•Remote

About The Position

Mayo Clinic is seeking a mid- to senior-level Software Engineer to join the Omniverse & Digital Twin Platform team. This team is part of Mayo Clinic's Bold. Forward. Unbound. initiative, a significant infrastructure transformation focused on integrating AI, robotics, and digital technologies to revolutionize patient care. The role involves architecting and developing simulation environments and digital twin systems using NVIDIA Omniverse. These systems will enable virtual modeling, testing, and optimization of clinical workflows, facility operations, medical robotics, and patient experiences prior to physical construction, ultimately supporting the initiative's goal of advancing cures and improving patient outcomes.

Requirements

Mid- to senior-level Software Engineer experience
Experience with NVIDIA Omniverse
Experience with OpenUSD
Experience with Autodesk Maya, Blender, 3ds Max, ZBrush, Substance Painter/Designer, and Photoshop
Experience with NVIDIA Isaac Sim and Isaac Lab
Experience with Python and C++
Experience with USD-based pipelines
Experience with AI/ML model training
Experience with computer vision
Experience with AR/VR or spatial computing
Experience with clinical informatics
Experience with Epic EHR systems
Experience with RTLS platforms
Experience with BAS/BMS infrastructure
Experience with agile methodologies
Ability to operate autonomously in a fast-moving, unstructured environment
Ability to manage shifting priorities and aggressive timelines

Nice To Haves

Experience with digital twin development
Experience with simulation environments
Experience with real-time rendering
Experience with physics-based simulation
Experience with synthetic data generation
Experience with NVIDIA Cosmos foundation models
Experience with cloud and on-premises GPU infrastructure

Responsibilities

Model, texture, and light high-fidelity 3D environments based on real physical spaces for workflow, robotics simulation, and training.
Create detailed assets components, work cells, props, and clinical environments optimized for real-time rendering.
Apply strong artistic fundamentals – form, color, proportion, and composition – to produce visually coherent scenes.
Design and build high-fidelity digital twins of clinical facilities, care neighborhoods, operating rooms, robotics systems, and logistics centers using NVIDIA Omniverse and OpenUSD.
Integrate real-time sensor data, BIM/CAD models (Revit), and IoT streams to keep digital twin state synchronized with physical campus conditions.
Develop simulation environments for workflow modeling — patient flow, staff routing, equipment utilization, and supply chain logistics — to inform facility design and operations.
Iterate on assets based on performance needs, simulation accuracy, and multi-disciplinary team feedback.
Utilize industry standard tools such as Autodesk Maya, Blender, 3ds Max, ZBrush, Substance Painter/Designer, and Photoshop.
Maintain clean, efficient asset pipelines and documentation for repeatable simulation workflows.
Build physics-based simulation scenarios using NVIDIA Isaac Sim and Isaac Lab to test autonomous systems, AMRs, and robotic assistants planned for the new facilities.
Create synthetic data pipelines using Omniverse for training AI/ML models in clinical and operational contexts, supporting computer vision, detection, and safety systems.
Implement real-time physics simulation for validation of clinical workflows, equipment placement, and safety egress scenarios prior to construction milestones.
Validate visual and physical accuracy of simulation outputs to ensure alignment with real-world behavior.
Collaborate with AI Engineering, Development, and Simulation teams to refine assets and workflows.
Develop Omniverse extensions, connectors, and microservices using Python and C++ to integrate clinical applications, Epic EHR systems, RTLS platforms, and BAS/BMS infrastructure.
Build and maintain USD-based pipelines for ingesting, transforming, and versioning 3D assets including architectural models, medical equipment, and anatomy datasets.
Collaborate with infrastructure teams to deploy and scale Omniverse environments on NVIDIA-accelerated cloud and on-premises GPU infrastructure.
Partner with clinical informatics and AI teams to integrate predictive models and AI agents into simulation environments for decision support and operational optimization.
Develop immersive visualization interfaces (AR/VR, spatial computing) for surgical planning, staff training, and clinical design reviews.
Leverage NVIDIA Cosmos foundation models and synthetic data generation capabilities for AI model training in medical and operational domains.
Support demos/pilots, training content, and visual storytelling for leadership and stakeholders.
Work closely with architects, construction teams, clinical staff, and operations leaders to translate physical design intent into digital simulation.
Participate in agile sprint cycles, contributing to architecture reviews, design documentation, and cross-functional planning for the Bold. Forward. Unbound. program.
Mentor junior developers and contribute to a culture of innovation, knowledge-sharing, and technical excellence within the Omniverse team.
Operate autonomously in a fast-moving, unstructured environment while managing shifting priorities and aggressive timelines.