Senior Scientist

MSD • Rahway, NJ

5d • Onsite

About The Position

The Biologics Process Research & Development organization within our company's Research Laboratories is responsible for developing the drug substance manufacturing processes for our company's biologics pipeline. We work closely with colleagues in Discovery, Pre-clinical and Early Development to rapidly develop manufacturing processes for diverse biotherapeutics, and efficiently manufacture material to supply clinical trials. We are also responsible for commercial process development and development and implementation of new manufacturing technologies. We work with our partners in our company's Manufacturing Division to commercialize and launch new products. We are seeking a highly motivated and energetic individual to join our Process Cell Sciences (PCS) group as Senior Scientist. In this role, the successful candidate will work closely with team members of PCS and help develop and characterize mammalian production cell lines to support innovative biologics pipeline. Candidate must have experience in executing complex study designs requiring highly organized data collection and management. The selected candidate will be expected to work independently, including proactive planning, trouble shooting and successful execution of complex experimental protocols for cell line development and technology assessment. The selected candidate will be developed to serve as a technical lead and functional area representative on project teams.

Requirements

• In-depth understanding of cell biology/molecular biology and hands-on experience of molecular subcloning, vector design, and mammalian cell culture.
• Familiar with industrial cell line development workflow.
• Hands-on experience in designing and assembling synthetic genetic circuits using modular parts to incorporate transcriptional, translational, and post-translational regulation.
• Experienced in integrating systems biology models with large-scale datasets to predict the impact of genetic modifications on cell behavior and product quality.
• Experienced in cell line genetic characterization techniques (e.g., Southern blotting, gene copy number analysis, etc.).
• Excellent communication and interpersonal skills to work effectively in a team environment.
• Demonstrated ability to communicate complex issues in a succinct and logical manner.
• Strong technical writing skills.

Nice To Haves

• Experienced in regulatory filing and preparing relevant documentation.
• Familiar with regulatory guidelines related to biologics cell line development and cell bank characterization.
• Knowledge in genomics, transcriptomics, proteomics and genome editing technologies.
• Expertise of database and statistical software (e.g., JMP, Spotfire).
• Hands on experience in library construction and data management for DNA-seq and RNA-seq workflows.

Responsibilities

• Develop and characterize mammalian production cell lines to support innovative biologics pipeline.
• Execute complex study designs requiring highly organized data collection and management.
• Proactively plan, troubleshoot, and successfully execute complex experimental protocols for cell line development and technology assessment.
• Serve as a technical lead and functional area representative on project teams.

Benefits

• medical, dental, vision healthcare and other insurance benefits (for employee and family)
• retirement benefits, including 401(k)
• paid holidays
• vacation
• compassionate and sick days
• annual bonus
• long-term incentive

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree