Senior Scientist

Pfizer • Groton, CT

3d • $93,600 - $156,000 • Onsite

About The Position

We are seeking a synthetic organic chemist to join the Process Chemistry group within Chemical Research and Development (CRD) in Groton, CT. CRD, part of Preclinical and Translational Sciences within Pfizer R&D, is responsible for the development of process technology to produce active pharmaceutical ingredients (APIs). This work includes the synthesis of diverse chemical entities that support both traditional small molecules and emerging therapeutic modalities, including peptides, lipids and other complex synthetic molecules. CRD scientists engage in all facets of development from small scale synthesis in support of discovery programs, to the development of the commercial synthetic routes. CRD scientists partner with manufacturing specialists for API synthesis in kilo-lab and pilot plant facilities, as well as provide support for technology transfer to Pfizer manufacturing sites and third-party facilities.
The successful candidate will design, enable and develop scalable processes to pharmaceutical drug candidates, applying innovative chemistries, new technologies and statistical experimental design approaches in a laboratory setting. The ability to work on and lead multi-disciplinary teams involving chemists, analysts, engineers, and technologists, and to represent CRD on cross-functional teams is essential.

Requirements

• PhD. in Organic Chemistry (or within 9 months of completing Ph.D. program).
• No industrial experience required.
• State of the art knowledge of modern synthetic methodology, including aspects of asymmetric synthesis, green chemistry, catalysis and physical organic chemistry as it relates to reaction mechanism is expected.
• Excellent written and oral communication skills.
• The ability to effectively influence the work of others.
• A general knowledge of drug development and the pharmaceutical industry are key.
• Permanent work authorization in the United States.

Nice To Haves

• The ability to employ analytical tools, computational and statistical methodology, and automated laboratory technologies to enhance process development efficiency is desirable.
• Prior experience with peptide and lipid synthesis is highly valued, particularly hands-on experience with route development, scale-up, purification strategies, and cross-functional collaboration in support of pharmaceutical research and development, though it is not required.

Responsibilities

• Identify and utilize innovative approaches to develop robust synthetic routes for the preparation of drug candidates, including traditional small-molecules, peptides, lipids, and other complex synthetic modalities.
• Laboratory experimentation, participation in multi-disciplinary project teams, and collaboration with scientists from Analytical R&D and other disciplines, such as engineering, to further develop synthetic routes into scalable processes.
• Interpretation of analytical data to drive synthetic experimental plans and the ability to utilize electronic tools, such as an electronic notebook, to document information.
• Continuously develop and apply new scientific and technical skills.
• Participate in the preparation of technical transfer documents for manufacture internally or at third parties.
• Compliance with safety and regulatory requirements is expected and documented through our internal training program.
• Participate in key initiatives for CRD and contribute to continuous improvement work in the department and advancement of the process chemistry discipline through technology, workflow, or business impact.

Benefits

• 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
• Paid vacation, holiday and personal days
• Paid caregiver/parental and medical leave
• Health benefits to include medical, prescription drug, dental and vision coverage
• Relocation support available
• Relocation assistance may be available based on business needs and/or eligibility.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree