Senior Scientist - Oncology Translation Research (OTR)
About The Position
The Senior Scientist I/II in Oncology Pathology Biomarkers independently designs and delivers tissue-based biomarker studies supporting oncology programs from target discovery through clinical development. The role works across pathology, molecular biology, translational research, and data science, using advanced tissue assays, digital pathology, and spatial technologies to translate complex data into decision-enabling insights. This laboratory-based position is part of the Oncology Pathology Biomarkers team within Oncology Translational Research. It supports multiple oncology indications and therapeutic modalities using preclinical models and consented human tissue specimens. The position is onsite in Cambridge, Massachusetts, is not eligible for remote work, and currently requires no business travel.
Requirements
- Bachelor's or Master's degree in Biological Sciences, Pathology, Molecular Biology, Cell Biology, or a related discipline, with relevant laboratory experience.
- Hands-on experience with tissue-based biomarker methods such as immunohistochemistry, immunofluorescence, or in situ hybridisation.
- Experience optimising and troubleshooting biomarker assays and interpreting tissue-based experimental data.
- Ability to independently design and execute experiments, analyse complex datasets, and make clear recommendations.
- Working knowledge of molecular and cell biology methods such as cell culture, quantitative polymerase chain reaction, western blotting, or flow cytometry.
- Ability to manage multiple activities, prioritise deliverables, and collaborate effectively in a multidisciplinary matrix environment.
- Clear written and verbal communication skills, with basic proficiency in Microsoft Excel, PowerPoint, and Word.
Nice To Haves
- Experience using preclinical models and human tissue specimens in oncology translational research.
- Experience in basic pathology or tissue histology.
- Broad understanding of the drug discovery and development pipeline.
- Experience with digital pathology, whole-slide imaging, quantitative image analysis, or AI-enabled image-analysis platforms.
- Experience with spatial transcriptomics, spatial proteomics, multiplex tissue imaging, or related technologies.
- Experience transferring assays to or overseeing work performed by external partners or contract research organisations.
Responsibilities
- Independently design, execute, troubleshoot, and interpret biomarker studies addressing critical oncology project questions.
- Develop, optimise, validate, and apply immunohistochemistry, immunofluorescence, and in situ hybridisation assays.
- Perform quantitative whole-slide image analysis using digital pathology and AI-enabled platforms.
- Collaborate with subject-matter experts to characterise preclinical models and answer scientific and technical questions.
- Manage external research partners and contract research organisations, including assay transfers, milestones, data exchange, and deliverables.
- Maintain high standards for data integrity, biosafety, laboratory operations, and continuous improvement.
- Communicate findings and recommendations through project discussions, scientific presentations, and study reports.
Benefits
- Performance-based cash incentive.
- Depending on role level, eligibility to be considered for annual equity awards.
- Health benefits.
- Life benefits.
- Disability benefits.
- 401(k) with company contribution and match.
- Vacation, personal days, holidays, and other leaves.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
