Analytical Science and Technology Senior Scientist
About The Position
Vertex is seeking a highly motivated and experienced Senior Scientist to join the Analytical Science and Technology team. In this role, you will work closely with contract manufacturing organizations and a diverse, cross-functional group of scientists at Vertex to solve complex challenges encountered during late-stage development and commercial manufacturing of small-molecule drug products. The ideal candidate will have a strong scientific foundation and a proven track record of developing, implementing, and troubleshooting analytical methods within the pharmaceutical industry. This individual should thrive in a fast-paced environment and demonstrate the ability to collaborate effectively across cross-functional teams, communicate clearly, and drive solutions to support product development and commercial success.
Requirements
- Strong practical analytical chemistry skills across a range of general analytical techniques that must include (U)HPLC and GC
- Proven experience in analytical development or technical operations, supporting late-stage development, commercialization and post-approval activities
- Demonstrated expertise in problem-solving and root cause analysis for analytical related issues
- Strong technical knowledge of chromatographic methods, including HPLC, GC, and other analytical techniques commonly used in pharmaceutical analysis
- Experience applying compendial methods such as KF, elemental impurity testing, spectroscopic identification)
- Solid understanding of cGMP regulations, ICH guidelines and CMC regulatory expectations in a pharmaceutical setting
- Proficiency in data analysis, trending and visualization tools to support decision-making and process monitoring
- Strong communication, collaboration and technical writing skills
- Proven ability to work successfully in a fast-paced, matrixed environment while also operating independently with minimal supervision
- Strong project management skills and the flexibility to adjust to shifting project priorities and business needs
Responsibilities
- Designs and performs elaborate and technically challenging analytical experiments in compliance with applicable regulations and SOPs
- Lead analytical method transfer activities for small molecule drug product to CMOs or between internal groups
- Support method validation or co-validation activities for late-phase development and commercial programs
- Prepare, review, and approve technical documentation for commercial products, including analytical methods, SOPs, transfer protocols and reports, laboratory records, and technical reports.
- Serve as the primary analytical lead for external CMOs, overseeing analytical service execution, driving investigations, and partnering on process-related issue resolution
- Analyze and trend commercial data to support continued process verification, identify emerging issues, and inform data-driven decisions.
- Support product lifecycle management activities and implement continuous process improvement through commercial change control
Benefits
- annual bonus
- annual equity awards
- overtime pay
- medical benefits
- dental benefits
- vision benefits
- generous paid time off
- week-long company shutdown in the Summer
- week-long company shutdown in the Winter
- educational assistance programs
- student loan repayment
- generous commuting subsidy
- matching charitable donations
- 401(k)
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What This Job Offers
Job Type
Full-time
Career Level
Senior
