Senior Scientist

Advanced Regenerative Manufacturing Institute • Manchester, NH

31d • Onsite

About The Position

The Advanced Regenerative Manufacturing Institute (ARMI) IBioFabUSA is a Member-based non-profit, member-driven, public-private partnership with a mission to advance the bioeconomy and transform the future of human health. ARMI provides technical and wrap-around commercialization services to companies seeking to advance technologies that will contribute to this impact. ARMI is seeking a highly motivated scientist to join our growing Multi-Omics group to develop and apply state-of-the-art methodologies to interrogate small molecule signatures within our bioprocesses. The successful candidate will spearhead efforts to characterize metabolomics and lipidomics profiles across processes in manufacturing cell-based therapy products, collaborating across groups for multi-omic analysis. The ideal candidate will have demonstrated expertise in untargeted metabolomics and/or lipidomics and extensive hands-on experience with sample handling automation, LC-MS instrumentation, and data analysis software platforms.

Requirements

• Degree in Chemistry, Biochemistry, Biotechnology or related area.
• MS with 5-10 years of experience or PhD with 2-5 years postgraduate experience.
• Significant hands-on experience across all stages of untargeted small molecule analyses: sample preparation, mass spectrometric analyses, and data processing and interpretation.
• Familiarity with lab automation and higher-throughput workflows.
• Good communication skills, proactive attitude, and results-driven mindset.

Nice To Haves

• Experience with Biomek systems is a plus.

Responsibilities

• Develop an optimized pipeline for deep, untargeted analysis of polar metabolites and lipids from bioreactor cultured cells and conditioned media.
• Prepare bioreactor samples for liquid chromatography-mass spectrometry analysis, leveraging automation for improved throughput.
• Operate and maintain Thermo LC-MS instrumentation, including Vanquish UHPLC, Exploris 480, and IQ-X.
• Analyze LC-MS raw data with processing software including Compound Discoverer, LipidSearch, MZmine, and Python/R scripting.
• Collaborate closely within the Multi-Omics group and across Process Development and Data Science groups to discover and communicate biological insights that will deliver impact.
• Engage with Operations Support, service engineers, and vendors for instrument maintenance, optimization, and upgrades.
• Adhere to safety and quality guidelines and SOPs.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior