Senior Scientist, Upstream Viral Process Development

Dispatch Bio • Philadelphia, PA

5d

About The Position

Our purpose at Dispatch is to help create a world where all cancer patients can be cured. We’re humbled by the opportunity to work together as a team on some of the most pressing medical challenges of our time. To achieve our purpose, we are dedicated to engineering a universal treatment across solid tumors. We’re committed to the development of novel therapies, leveraging first-in-class technologies in viral vectors, universal targets, and novel cytokine biology. Our therapeutic approach has the potential to enable us to treat significant numbers of cancer patients and make a real and lasting impact on the world. Our company was founded on pioneering work carried out in the laboratories of Dr. Carl June (University of Pennsylvania), Dr. Kole Roybal (University of California, San Francisco), Dr. Christopher Garcia (Stanford University) and Dr. Andy Minn (Memorial Sloan Kettering Cancer Center). At our company, you would become one of our early team members— not only playing a role in meeting our ambitious mission but also building our thriving culture. We are determined to deliver with urgency to discover new solutions and we always stay dedicated to scientific rigor; we have an ownership mindset because each and every one of us is integral to our success. Collaboration is core for us because we believe that by bringing people together with diverse perspectives, we make a stronger whole. And, we show we care about our work and each other by sharing feedback - ultimately in service of our vision to empower people to continue forward with their lives – cancer free.

Requirements

• Bachelor’s Degree in Chemical Engineering, Biochemical Engineering/Bioengineering, Biotechnology or related discipline with at least 10 years of relevant experience -OR- Master's Degree with 8 years -OR- PhD with 5 years
• Hands-on experience with viral vector upstream processing, including excellent small-scale aseptic technique and expert understanding of bioreactor operation and control loops
• Experience implementing processes in clinical and commercial manufacturing of cell and gene therapy/biopharma products
• Demonstrated ability to apply knowledge of cell biology, chemical engineering or bioengineering toward process development, scale-up/scale-down and troubleshooting
• Strong scientific reasoning, problem-solving, and applied mathematics and statistics skills, including the ability to break down complex problems into manageable hypotheses
• Proven experience collaborating with internal and external partners
• Ability to balance individual contributions while training and informally mentoring junior colleagues
• Working knowledge of GMP guidelines for clinical and commercial manufacturing
• Proficiency in using Microsoft Word, Excel, Power Point and data analysis/presentation software such as JMP and/or GraphPad
• Excellent interpersonal, verbal and written communication skills
• Strong organizational & problem-solving skills, with excellent attention to detail and the proven ability to collaborate in a dynamic team environment

Nice To Haves

• Hands-on plasmid manufacturing experience or oversight of external plasmid manufacturing partners
• End-to-end experience in Lentivirus and Adenovirus development and manufacturing
• High-throughput bioreactors systems
• Drafting CMC sections for INDs
• Use of Artificial Intelligence (AI) to develop efficiencies and assist in tackling complex problems

Responsibilities

• Contribute to the setup and organization of the company’s vector process development capabilities.
• Develop bench scale suspension culture processes for viral vector generation within shake flasks and bioreactors through design and execution of experiments to support process characterization, and process transfer activities between the research team, TechOps, and external partners.
• Provide experimental execution, data review and analysis, and maintenance of accurate and detailed lab notebooks.
• Perform day-to-day activities in the vector process development lab including maintaining equipment, ordering materials and managing inventory, and preparing buffers and process aids.
• Author and review technical documents, including but not limited to batch records, SOPs, development reports and process-specific sections of regulatory documents.
• Represent the company externally at meetings (professional associations, with regulatory bodies, etc.).
• Serve as a PD subject matter expert on both internal and external teams (CDMO, material & equipment suppliers, etc.).

Benefits

• Highly competitive compensation package with meaningful ownership through equity
• Excellent coverage for medical, vision, and dental
• 401(k) with generous contribution
• Life insurance
• Flexible PTO policy
• Additional substantial benefits

What This Job Offers

• Job Type: Full-time
• Career Level: Senior