Senior Scientist, Translational Research (Immunohistochemistry)

Crescent Biopharma•Waltham, MA

8d•$170,000 - $190,000

About The Position

Crescent Biopharma is seeking an experienced, highly motivated Senior Scientist to join its Research organization. The role advances tissue-based biomarker strategies across the oncology portfolio, with an emphasis on immunohistochemistry (IHC), translational biology, and biomarker development. The scientist will lead the design, execution, and interpretation of tissue-based translational studies supporting discovery and preclinical-stage programs, developing and implementing biomarker strategies to improve understanding of target biology and expression, mechanism of action, and pharmacodynamic activity. The position works closely with Research, Translational Medicine, Clinical Development, Regulatory Affairs, and external partners to generate data that informs development decisions and supports precision medicine approaches.

Requirements

PhD in Cancer Biology, Immunology, Pathology, Molecular Biology, Cell Biology, or a related discipline.
5–7 years of industry experience, or equivalent postdoctoral and industry experience, in translational research, biomarker sciences, or oncology drug development.
Extensive hands-on experience with immunohistochemistry (IHC) assay development, optimization, and interpretation using human tissue samples.
Strong understanding of tumor biology, tumor microenvironment biology, and translational oncology.
Experience working with external CROs and managing outsourced studies.
Demonstrated ability to independently design experiments and interpret complex biological datasets.
Strong communication, presentation, and scientific writing skills.
Proven ability to thrive in a collaborative, fast-paced biotechnology environment.

Nice To Haves

Experience with multiplex IHC/IF, digital pathology, image analysis platforms, and spatial biology technologies.
Knowledge of biomarker development for early-phase clinical trials.
Familiarity with RNAscope, GeoMx, CosMx, Visium, Akoya, or related platforms.
Experience supporting IND-enabling or clinical development programs.
Background in oncology, immuno-oncology, antibody therapeutics, ADCs, or targeted therapies.

Responsibilities

Lead development and execution of translational biomarker strategies across multiple oncology programs.
Design, oversee, and interpret IHC, multiplex IHC/immunofluorescence, and other tissue-based biomarker studies.
Manage biomarker studies conducted through CROs and external laboratory partners, including assay development, validation, data review, troubleshooting, and scientific oversight.
Analyze and integrate tissue biomarker data with genomic, transcriptomic, and clinical datasets to generate actionable insights.
Contribute to study reports, regulatory submissions, clinical protocols, investigator brochures, and scientific publications.
Collaborate with cross-functional teams to identify biomarkers supporting mechanism of action, pharmacodynamic activity, resistance mechanisms, and potential patient stratification.
Evaluate and implement emerging technologies in digital pathology, multiplex imaging, spatial biology, and tissue analytics.
Present scientific findings to internal teams, senior leadership, and external collaborators.

Benefits

Competitive compensation, including base salary, performance bonus, and equity.
100% employer-paid benefits package.
Flexible PTO, including unlimited vacation PTO as described in the pay transparency information.
Two one-week company-wide shutdowns each year; holiday pay includes company shutdowns.
Professional development resources, mentorship, and growth opportunities.
Medical, dental, and vision insurance.
Life insurance and short- and long-term disability.
401(k) savings plan.
Long-term incentive program.
10 days of sick time per calendar year.
16 weeks of parental leave within one year of the birth, adoption, or foster care of a child.
FMLA and military leave.