Senior Scientist, Surface Chemistry
About The Position
This role is a major contributor to the development and optimization of CMOS chip-based DNA synthesis workflows, encompassing both phosphoramidite and enzymatic chemistries. The scientist will develop and optimize electrochemical synthesis protocols, including chip handling, hardware configuration, software integration, and process troubleshooting. A key aspect of the role involves investigating and refining surface functionalization strategies to enhance synthesis efficiency and fidelity. The position requires collaboration with engineering and synthesis teams to build and iterate prototype testbeds, integrating chemistry, fluidics, and hardware systems. The scientist will operate NGS-based analytical pipelines for quality assessment of oligonucleotide pools and analyze experimental data using molecular biology and organic chemistry techniques. A significant responsibility includes driving technology transfer from R&D to manufacturing, ensuring robust scale-up and process documentation. The role also involves defining and executing scientific and technical objectives aligned with company goals, presenting experimental plans and results, and maintaining detailed records of all experimental work and analysis.
Requirements
- Advanced degree (PhD) in Chemistry, Organic Chemistry, Chemical Engineering, or a closely related field.
- Experienced MS or BS candidates with significant relevant experience will also be considered.
- Proven track record and proficiency in phosphoramidite oligonucleotide synthesis chemistry and platform development
- Strong understanding of DNA chip technologies and synthetic biology applications
- Demonstrated ability to participate cross-functional projects and collaborate across R&D and manufacturing teams
- Excellent problem-solving, communication, and project management skills
Nice To Haves
- Experience in a biotech or pharma R&D environment is highly desirable.
- Experience in oligonucleotide microarray or pool synthesis is highly desirable
- Hands-on experience with NGS workflows and data analysis is highly desirable
- Familiarity with software scripting for synthesis automation
Responsibilities
- Major contributor to the development and optimization of CMOS chip-based DNA synthesis workflows, including both phosphoramidite and enzymatic chemistries
- Develop and optimize electrochemical synthesis protocols, including chip handling, hardware configuration and software integration, and process troubleshooting
- Investigate and refine surface functionalization strategies to improve synthesis efficiency and fidelity
- Collaborate with engineering and synthesis teams to build and iterate prototype testbeds, integrating chemistry, fluidics, and hardware systems
- Operate NGS-based analytical pipelines for quality assessment of oligonucleotide pools
- Analyze experimental data using molecular biology and organic chemistry techniques
- Drive technology transfer from R&D to manufacturing, ensuring robust scale-up and process documentation
- Help define and execute scientific and technical objectives aligned with company goals
- Present experimental plans, results, conclusions, and next steps at group meetings, project team meetings, and company-wide meetings.
- Maintain detailed and meticulous records of all experimental work and analysis.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
