Senior Scientist, Safety Assessment & Toxicology Data Analytics

Centessa Pharmaceuticals•Boston, MA

7d•Remote

About The Position

Centessa Pharmaceuticals is seeking an analytically elite, strategically minded Senior Scientist to join their Safety Assessment team. This is a 100% non-laboratory position for a seasoned bioscientist or toxicology operations expert skilled in dataset auditing, mechanistic evaluation, and cross-functional project leadership. The Senior Scientist will act as a scientific and strategic liaison between Centessa’s internal toxicology leaders, Project Development Teams (PDTs), and other departments such as DMPK, CMC, Regulatory, and Clinical Operations. The role involves owning the analytical pipeline for toxicology studies, including auditing regulatory SEND datasets, creating data visualizations for toxicology endpoints, and writing literature reviews. The insights generated will influence investigative toxicology strategies, guide early pipeline decisions, and support project endorsements at internal governance committees.

Requirements

B.S. or M.S. degree in Toxicology, Pharmacology, Cellular/Molecular Biology, Bioinformatics, or a related life sciences discipline.
With an M.S. degree: 6–8+ years of relevant biotechnology, pharmaceutical, or tier-one CRO industry experience.
With a B.S. degree: 8–10+ years of extensive industrial drug-development, data management, and toxicology operations experience.
Expert-level understanding of preclinical toxicology datasets, histopathology reporting structures, and study designs.
Hands-on proficiency auditing, validating, or working directly with regulatory SEND data structures.
Advanced capability utilizing scientific data software to build complex data structures (e.g., GraphPad Prism, Spotfire, Excel macros, or specialized Python/R data visual tools).
Superb technical writing skills.
Demonstrated ability to distill complex data into clear arguments for diverse, cross-functional scientific leaders.

Responsibilities

Lead the architectural design and execution of data models to transform raw toxicology data, clinical pathology tables, and safety pharmacology metrics into visual tools (e.g., exposure-margin heatmaps, benchmark dose plots, cumulative trend diagnostics) to define therapeutic windows.
Oversee the review and quality control of incoming Standard for the Exchange of Nonclinical Data (SEND) datasets from CRO vendors, ensuring compliance, schema validation, and data alignment with study reports for regulatory filing and archival.
Conduct scientific literature investigations to assess target-mediated or chemotype-specific safety risks and synthesize complex biological data into actionable technical memos for investigative toxicity strategies.
Partner with Toxicology Leads to co-author data packages, briefing books, and executive slide decks for defending safety strategies and securing program endorsements within Project Development Teams (PDTs) and governance panels.
Serve as a senior scientific liaison between Safety Assessment, CMC, DMPK, and Project Management to ensure nonclinical safety deliverables align with global project milestones.