Senior Scientist, Reagents Sustaining and Applications (P-5010)

10x Genomics•Pleasanton, CA

23h•Onsite

About The Position

We are seeking a Senior Scientist to join the Reagent Sustaining and Applications group to lead sustaining efforts for our Chromium Single Cell products. The role interfaces with R&D, Production, Marketing, and Support to provide the best products to our customers from pre-launch to end of life. The ideal candidate should have deep expertise in product development, troubleshooting complex issues, and understanding of molecular biology, including single cell assays, reagent manufacturing, and developing assays for quality control or manufacturing environments. What you will be doing: Lead efforts in testing new materials, tools, and workflows to improve 10x’s state-of-the-art products. Collaborate with key internal and external partners to troubleshoot and mitigate any issues that may arise in 10x’s Chromium product line. Design and execute experiments to assess the impact of protocol, reagent, or process changes on 10x’s Assays. Design, test, and implement process improvements in 10x’s Chromium product line. Perform statistical analyses on key assay and QC metrics. Update manufacturing documents and present results.

Requirements

BS, MS or PhD in molecular biology, biochemistry, genetics, microbiology, analytical chemistry, or related fields.
12+ years (BS), 10+ years (MS) or 5+ years (PhD) of relevant experience in reagent or assay development and optimization, preferably in the Biotechnology industry.
Experience analyzing large-scale single-cell or spatial transcriptomics datasets to derive biologically meaningful insights and/or diagnostic biomarkers.
Ability to design and execute experiments to measure the impact of process improvements and/or formulation changes.
Experience with a broad variety of molecular biology and analytical techniques including qPCR, nucleic acid isolation, use of plate readers, Bioanalyzers, gel imagers, real-time PCR instruments, etc.
Experience with single cell assays including cell handling, library preparation and downstream analysis.
Experience investigating, identifying, documenting, communicating, and resolving quality control issues in a controlled manufacturing environment.
Experience defining, documenting, communicating, and transferring new manufacturing workflows into controlled manufacturing environments.
Meticulous attention to detail and a conscientious work ethic.

Nice To Haves

Hands-on experience with the 10x Chromium platform.
Experience using statistical tools, such as JMP or R to analyze complex data sets, create DOE experiments, and create data trending reports.
Experience with bioinformatic analysis of Next Generation Sequencing data from Illumina platforms.
Previous experience supervising and/or mentoring junior staff or leading a multifunctional project team.
Ability to prioritize competing projects based on impact and alignment with company goals.

Responsibilities

Lead efforts in testing new materials, tools, and workflows to improve 10x’s state-of-the-art products.
Collaborate with key internal and external partners to troubleshoot and mitigate any issues that may arise in 10x’s Chromium product line.
Design and execute experiments to assess the impact of protocol, reagent, or process changes on 10x’s Assays.
Design, test, and implement process improvements in 10x’s Chromium product line.
Perform statistical analyses on key assay and QC metrics.
Update manufacturing documents and present results.