Senior Scientist, Process Analytical Technologies

Merck•Upper Gwynedd Township, PA

9d•$117,000 - $184,200•Onsite

About The Position

We are seeking a Senior Scientist to join the Process Analytical Technologies (PAT) team within Analytical Enabling Capabilities (AEC). In this role, you will collaborate with a cross-functional, highly engaged team to advance the development pipeline and support commercial manufacturing. The successful candidate will lead the development, validation, and implementation of in-line, on-line, and at-line PAT solutions for both small- and large-molecule modalities. This position offers the opportunity to make a meaningful impact by advancing real-time analytical capabilities, enabling process monitoring and control, as well as supporting technology transfer and launch readiness efforts for programs progressing from early development into manufacturing.

Requirements

Technical background in spectroscopy (Raman, FTIR, NIR), chromatography, and chemometric/modeling approaches.
Adaptability
Analytical Method Development
Bioanalytical Analysis
Biological Engineering
Biotechnology
Chemical Engineering
Chemical Technology
Chemistry
Chromatographic Techniques
Chromatography
Fourier-Transform Infrared Spectroscopy (FTIR)
Innovative Thinking
Manufacturing Support
Near Infrared Spectroscopy (NIRS)
Process Analytical Technology (PAT)
Spectroscopy
Strategic Thinking
Technical Writing

Nice To Haves

Experience supporting tech transfer, manufacturing scale-up, or regulatory filings.
Proven track record of scientific contributions (peer-reviewed publications or equivalent technical outputs).
Strong collaborative and interpersonal skills; ability to work across functions and with external partners.

Responsibilities

Develop, validate, and implement PAT methods (in-line, on-line, at-line) to monitor and control process parameters and product quality attributes.
Support the systematic assessment and deployment of in-line, on-line, and at-line PAT methods across small- and large molecule programs.
Deploy standardized analytical platforms to enable PAT implementation, including real-time monitoring and rapid shop-floor analytics.
Support the scale-up activities and technology transfer of PAT applications to commercial manufacturing.
Partner with capital project and facility teams to deploy integrated PAT infrastructure aligned with the launch preparedness strategy.
Prepare and maintain scientific documentation and validation packages for PAT methods; contribute content for regulatory submissions.