Senior Scientist - Modeler

PerkinElmer•Collegeville, PA

3d•$100,000 - $130,000•Onsite

About The Position

When joining PerkinElmer, you select an experienced and trusted leader in scientific solutions, with the support of a global service network and distribution centers, providing the right solution, at the right time, to meet critical customer needs. With over an 80+ year legacy of advancing science and a mission of innovating for a healthier world, our dedicated team collaborates closely with commercial, government, academic and healthcare customers to deliver our broad portfolio of analytical solutions, and OneSource services. Job Description We are seeking a highly motivated and ambitious candidate to join the PerkinElmer OneSource Scientific Services team based at one of our customer sites in Collegeville, PA. The successful candidate will be working within the PerkinElmer Technical Lab Services (TLS) division and will be placed within a research unit at the customer site who have a focus on process engineering and modeling, supporting R&D and manufacturing activities and are at the forefront of developing innovative and life-changing medicines for patients. The candidate will work within a collaborative team environment across a diverse biotherapeutic portfolio within the company and can develop in PerkinElmer’s scientific arena. The role will report to the PerkinElmer Regional TLS Leader and will be based at the GSK Upper Providence campus.

Requirements

Strong communication and interpersonal skills, both written and verbal.
Self-motivated and able to work under pressure to prioritize conflicting deadlines.
An ability to meet timelines successfully with the utmost attention to detail while setting high performance standards.
Service orientated attitude combined with innovative thinking.
Strong interpersonal skills; strong team player with customer satisfaction focus
Ability to execute new and established methods and protocols.
Ability to understand, interpret, and communicate complex scientific data.
Understanding of standard software packages (i.e. Microsoft Office).
Ability to operate within company and/or customer site safety codes of practice.
BSc or equivalent in a relevant scientific subject (e.g. Engineering, Process Engineering and Modeling).
2 years of demonstrated technical expertise in applying simulation to process development.
Ability to program in and transfer mathematical models to languages such as Matlab, Python, or gPROMS.
Knowledgeable in good laboratory practices (GLP), good laboratory safety practices, and data integrity principles.

Nice To Haves

Masters or Doctorate qualification in a relevant scientific subject (e.g. Engineering, Process Engineering and Modeling).
3+ years of previous pharmaceutical industry experience.
Publications in peer-reviewed journals.
Computational skills preferred for enabling automated data acquisition and analysis, and familiarity with related data analysis applications.
Knowledge of GCP, GCLP and GMP principles in the pharmaceutical environment.
Knowledge of 5S and/or 6 sigma principles is a plus.

Responsibilities

Create and maintain key models on company-wide platforms.
Develop and implement chemometric process models.
Establish, optimize, and troubleshoot hybrid/mechanistic process models.
Use mechanistic, data driven and hybrid modelling to efficiently deliver priority team objectives including but not limited to process design, quantitative risk assessment, identification of Critical Process Parameters, design space definition, and implementation of advanced model-based process monitoring and controls.
Use engineering, chemical or materials science knowledge to postulate mechanisms for physiochemical processes and develop or modify existing mathematical models to describe those mechanisms.
Translate mathematical models to computer models using software platforms (e.g. gPROMS, Aspen and DynoChem) or by writing custom programs (Using Matlab, Python, etc.) and integrate models into process development.
Drug Product technology transfer activities and reports as appropriate for transfer/scale-up to the manufacturing site (internal or external).
Preparation and review of developmental and manufacturing batch records, SOPs, and regulatory documentation as appropriate.
Automate developmental work packages and establish control strategies through the development and maintenance of system modeling platforms.
Conception & evaluation of conventional & novel product matrices and administration modalities.
Track assay performance metrics and communicate issues and suggest improvements to current assay methodology, supporting evaluation of new technologies where applicable.
Comply with Health and Safety procedures for own well-being and quality of product.
Actively seek opportunities to develop the service by discussion with the team leader and customer or by sharing the best practice with other groups.
Act as an ambassador for TLS and promote PerkinElmer’s core values.
Operate to approved quality standards.
Nothing in this job description restricts management’s right to assign or reassign duties and responsibilities of this job at any time.