Senior Scientist – Mixed modality Purification Scientist

Merck • Rahway, NJ

1d • Hybrid

About The Position

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to use innovative thinking, state-of-the-art facilities, and robust scientific methodology, we collaborate to discover the next medical breakthrough.
As a Senior Scientist in the multiscale separations team within the Separations Sciences team of Analytical Enabling Capabilities, you will work within a highly collaborative team to enable the advancement of the development pipeline. You will be primarily responsible for chromatographic isolation of pharmaceutical API and impurities from analytical scale to semi-prep scale and prep scale, covering the space of small molecules, peptides, conjugate-based modalities as well as emerging modalities in our portfolio. To accelerate the development of new medicines and vaccines, you will partner with process chemists and analytical scientists to deploy efficient and fit-for-purpose chemical isolation methods, to establish innovative purification workflows, and to deliver high purity materials. As a member of our team, you will be joining a diverse group of scientific problem solvers, who are dedicated to creating the life-changing products of tomorrow.

Requirements

• Ph.D. in Chemistry or a related field (expected completion no later than July 2026) with a minimum of 0+ years of experience in biopharmaceutical industry.
• M.S. with a minimum of 5 years of experience in the biopharmaceutical industry
• Expertise in analytical, semi-prep/prep scale chromatography (RPLC, NPLC, SFC), technologies, instrumentation, and workflows, with demonstrated experience in its applications in chiral, achiral isolation of challenging pharmaceutical mixtures to support a variety of pharmaceutical modalities including small molecules, peptides, antibody-drug conjugates and vaccines adjuvants etc.
• Method development for purification from mg to multigram material.
• Experience in mass spectrometry and its application in MS-directed chromatographic purification.
• Working knowledge of orthogonal detection technologies, including PDA, Multi-angle light scattering, charged aerosol detection etc.
• Foundational understanding of the principles around column retention mechanisms and their impact on chromatographic separations.
• Excellent scientific writing and verbal communication skills.

Nice To Haves

• Pharmaceutical GMP experience is highly preferred.
• Large scale purification on the order of a few kg.

Responsibilities

• Chromatographic isolation of pharmaceutical API and impurities from analytical scale to semi-prep scale and prep scale, covering the space of small molecules, peptides, conjugate-based modalities as well as emerging modalities in our portfolio.
• Partner with process chemists and analytical scientists to deploy efficient and fit-for-purpose chemical isolation methods.
• Establish innovative purification workflows.
• Deliver high purity materials.
• Creative problem solving in scientific research and development, with proven track-record of translating R&D problem solving into impactful pipeline deliveries.
• External scientific engagement that may include a combination of publications, industry white paper contributions, presentations at scientific meetings.
• Mentoring peers.

Benefits

• medical, dental, vision healthcare and other insurance benefits (for employee and family)
• retirement benefits, including 401(k)
• paid holidays
• vacation
• compassionate and sick days
• annual bonus
• long-term incentive

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees