Senior Scientist - Imaging

Regeneron Pharmaceuticals•Tarrytown, GA

2d•$109,900 - $179,300•Onsite

About The Position

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Senior Scientist, MRI to join our Imaging team. The successful candidate will work with the Imaging team's Lead MRI Scientist to execute preclinical MRI studies of rodent models, in collaboration with various therapeutic focus areas, technology teams, and imaging scientists at Regeneron. This will involve coordinating with scientists on experimental design, planning and scheduling animal imaging sessions, acquiring MR images using the 7T Bruker BioSpin system, and ensuring MRI data are relevant, actionable, and of high quality. These data and derived results will be packaged for communication to Regeneron's broader scientific community. You will also collaborate with imaging and therapeutic focus area scientists to optimize and develop MRI protocols for a variety of new MRI techniques and animal models. Current and emerging projects include T1, T2, and T2 mapping of major organs to study iron overload in a mouse model; neuroanatomical volume measurements from high-resolution in vivo brain imaging to measure volumetric brain changes associated with aging and disease; high-resolution anatomical imaging of the inner ear; and magnetic resonance spectroscopy to measure local brain metabolite concentration in genetic models of metabolic disorders. Regeneron's broad biological focus guarantees that you will always have something new to learn and contribute to.

Requirements

An MSc or PhD in Engineering, Biophysics, Biology, Chemistry, or a similar field
5+ years of experience operating in vivo rodent MRI
5+ years of in vivo mouse/rat handling, including anesthesia, injections, and tissue processing
Prior experience with 3D MRI visualization software such as 3D Slicer, ITK Snap, or ImageJ
Knowledge of basic MRI science and the ability to communicate it to a general audience
Knowledge of mouse and rat anatomy, with the ability to incorporate this into MRI study design
Exceptional critical thinking, attention to detail, scientific rigor, and strong analytical, problem-solving, and troubleshooting skills
The ability to shift focus between multiple projects while still meeting deadlines
A proven ability to work independently and collaboratively as part of a larger project
A positive attitude and willingness to learn new things
A passion for biology and helping others
A dedication to sharing, collaborating, and lifting others up

Nice To Haves

Prior experience with Bruker ParaVision software
MRI protocol development
Cardiac/respiratory/functional gating or triggering techniques
MRI/MRS processing software (VivoQuant, Amira, LCModel, FID-A, FSL, etc.)

Responsibilities

Working closely with the lead MRI scientist to understand project needs and priorities, troubleshoot experiments, and provide updates on project progress
Independently executing projects planned in consultation with the lead MRI scientist and in collaboration with scientists and specialists in Imaging and relevant therapeutic focus areas
Operating and optimizing the high field strength MRI for in vivo and ex vivo studies of preclinical rodent models, including critical evaluation of data acquisition
Performing relevant animal handling, such as administration of anesthesia, preparing animals for scanning, administration of contrast agents, animal monitoring, and preparation of tissue for ex vivo imaging
Maintaining online and physical records of data from ongoing and completed projects