Senior Scientist II, Rheumatology

AbbVie•Cambridge, MA

15h

About The Position

AbbVie’s Discovery Immunology R&D organization is seeking a highly motivated and innovative Senior Scientist II to join the Rheumatology team at the Cambridge Research Center (CRC). This individual will support preclinical drug discovery programs in rheumatology, with focus on Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA). The role emphasizes target validation, mechanism-of-action studies, translational research, and advancement of novel therapeutic strategies. The ideal candidate will bring deep expertise in immunology and inflammation biology, strong preclinical pharmacology experience, and hands-on knowledge of in vivo disease models. Success in this role requires the ability to integrate human disease biology with preclinical approaches, generate high-quality data packages, collaborate cross-functionally, independently drive scientific initiatives, and contribute to program strategy.

Requirements

Bachelor’s Degree with 12 years of experience, Master’s Degree with 10 years of experience, PhD with 4 years of experience.
Proven expertise in in vitro and preclinical in vivo model systems
Excellent interpersonal, communication, and collaboration skills
Ability to work effectively in a highly collaborative environment, including cross-functional teams and colleagues across multiple locations to support team and company goals.

Nice To Haves

Prior experience in the pharmaceutical or biotechnology industry is preferred.

Responsibilities

Serve as a functional representative responsible for setting Rheumatology strategy for pipeline programs and contributing to target evaluation and model development.
Drive in vitro and in vivo pharmacology for drug candidates, including establishing PK/PD relationships, developing, and optimizing screening assays, designing and executing mechanism-of-action studies, and evaluating candidate efficacy.
Develop acute and/or chronic murine models of inflammation to support preclinical development of candidates for rheumatological and other autoimmune diseases.
Apply immunological techniques such as flow cytometry, PCR/gene expression analysis, protein and cytokine quantification, histopathology, and other relevant functional readouts.
Design experiments, analyze data, and present findings at AbbVie scientific forums and external conferences.
Author and review technical reports, protocols, and other key scientific documents.
Adhere to corporate standards related to code of conduct, documentation, safety, proper handling of materials, and humane treatment of laboratory animals.